| 中华大蒜油对大鼠实验性高脂血症的防治作用 |
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| 引用本文： | 乔海灵,张莉蓉,贾琳静,张启堂,刘凤芝. 中华大蒜油对大鼠实验性高脂血症的防治作用[J]. 郑州大学学报(医学版), 2002, 37(3): 318-320 |
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| 作者姓名： | 乔海灵 张莉蓉 贾琳静 张启堂 刘凤芝 |
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| 作者单位： | 郑州大学基础医学院临床药理学教研室,郑州,450052 |
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| 摘 要： | 目的：研究中华大蒜油对大鼠实验性高脂血症的防治作用。方法：SD大鼠50只随机分为空白对照组、高脂模型组、低剂量组、高剂量组和绞股蓝总甙阳性对照组。第1组大鼠给予普通饲料，第2－5组均给予高脂饲料，第3、4组分别g中华大蒜油1．5mg/kg和3mg/kg，第5组ig胶股蓝总甙60mg/kg。每d给药1次，连续28d。酶法测定甘油三酯（TG）、胆固醇（TC）、低密度脂蛋白（LDL－C）、高密度脂蛋白（HDL－C）和极低密度脂蛋白（VLDL－C）的含量。计算动脉粥样硬化指数（AL）。结果：中华大蒜油可明显降低高脂血症模型大鼠血清TG、TC、LDL－C、VLDL－C，并能明显降低AI。结论：中华大蒜油对大鼠实验性高脂血症具有明显防治作用。
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| 关 键 词： | 中华大蒜油 高脂血症 防治 动物实验 |
| 修稿时间： | 2001-12-25 |
Preventive and treatment effects of garlic essential oil on experimental hyperlipidemia in rats |
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| QIAO Hailing,ZHANG Lirong,JIA Linjing,ZHANG Qitang,LIU Fengzhi. Preventive and treatment effects of garlic essential oil on experimental hyperlipidemia in rats[J]. Journal of Zhengzhou University: Med Sci, 2002, 37(3): 318-320 |
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| Authors: | QIAO Hailing ZHANG Lirong JIA Linjing ZHANG Qitang LIU Fengzhi |
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| Affiliation: | QIAO Hailing,ZHANG Lirong,JIA Linjing,ZHANG Qitang,LIU FengzhiDepartment of Clinical Pharmacology,Basic Medical College,Zhengzhou University,Zhengzhou 450052 |
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| Abstract: | Aim: To study the effects of garlic essential oil on experimental hyperlipidermia in rats. Methods: A total of 50 rats were randomly allocated into 5 groups: sham control group, hyperlipidemia model group, low-dose garlic essential oil group, high-dose garlic essential oil group, and positive control group. The levels of triglyceride (TG), total cholesterol(TC), low density lipid cholesterol (LDL-C), high density lipid cholesterol ( HDL-C), and VLDL-C were determined by enzyme method. The atherosclerosis oindex was calculated. Results: Garlic essential oil significantly decreased the serum contents of TG.TC, LDL-C, VLDL-C, and AI. Conclusion: Garlic essential oil can prevent and treat experimental hyperlipidemia in rats. |
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| Keywords: | garlic essential oil rat hyperlipidemia |
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