肝星状细胞及相关细胞因子在肝纤维化形成中的作用

肝纤维化(hepatic fibrosis)是指肝脏内弥漫性细胞外基质(extracellular matrix,ECM)过度沉积的病理过程.肝星状细胞(hepatic stellate cells,HSC)被认为是ECM的主要来源细胞,在肝纤维化发生发展中起着关键作用.另外,各种病因引起肝细胞损伤时,Kupffers细胞(KF),肝窦内皮细胞等分泌一系列细胞因子,通过旁分泌和自分泌方式作用于邻近的HSC,影响其增殖,趋化和ECM代谢.因此,HSC及细胞因子与肝纤维化的发生发展关系极为密切,阐明其关系,有助于以HSC为靶点的肝纤维化方面的研究,现就其关系分别综述如下.

Role of hepatic stellate cells and correlated cytokines in the formation of hepatic fibrosis

Hepatic fibrosis is a pathological process with excessive deposition of extracellular matrix(ECM)throughout the liver.Hepatic stellate cells(HSCs)are thought to be a major source of ECM and play a critical role in the process of hepatic fibrosis.In addition, when various pathogenic changes lead to hepatocyte damage,Kupffer's cells and liver sinus endothelial cells,among others,excrete a series of cytokines.These affect adjacent HSCs in a paracrine and autocrine manner,which influences the proliferation and inversion of HSCs and the metabolism of ECM.Therefore, there is a very close relationship between HSCs,cytokines and the course of hepatic fibrosis.Elucidating this relationship will benefit research on the role of HSCs in hepatic fibrosis.