阿奇霉素致27例肝损害的原因分析和预防对策

目的研究分析阿奇霉素致肝损害的一般规律并探讨预防对策,为临床合理使用阿奇霉素提供参考。方法通过检索维普全文数据库,对1999～2007年国内临床使用阿奇霉素出现肝损害的报道进行统计和分析。结果阿奇霉素所致肝损害的不良反应在各年龄段均有发生,但尤以儿童(<15岁)为多见。报道中所发生的肝损害患者的给药途径以静脉滴注为主,在口服给药中偶有发生。结论阿奇霉素所致肝损害与年龄、给药途径有一定的关系。与性别无关。与给药剂量、原患疾病、给药速度是否有关还需进一步的研究。

Analysis and Prevention of Liver Injury Caused by Azithromycin:a Retrospective Study of 27 Cases

OBJECTIVE To explore the general rules of liver injury caused by azithromycin and draw a preventive measurement,then provide a reasonable usage information for clinic.METHODS The case reports of liver injury caused by azithromycin were analyzed during the period from 1999 to 2007 by way of VIP database.RESULTS Liver injury can be seen in all age,but most happened on those whose age was below 15-years-old.The injury was mainly caused by intervenous drop infusion and occasionally happened by oral administration.CONCLUSION Liver injury caused by azithromycin is relate to age and the route of administration,and isn't relate to sex.Whether it is relate to the dosage,disease and administration's speed needs more research in the future.