| 喜树碱衍生物CZ48缓释纳米粒的制备及其体外释药特性考察 |
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| 引用本文： | 李思阳,孔庆新,王洋. 喜树碱衍生物CZ48缓释纳米粒的制备及其体外释药特性考察[J]. 中国实验方剂学杂志, 2014, 20(19): 5-7 |
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| 作者姓名： | 李思阳 孔庆新 王洋 |
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| 作者单位： | 江苏食品药品职业技术学院, 江苏 淮安 223003;东北林业大学盐碱地生物资源环境研究中心, 东北油田盐碱植被恢复与重建教育部重点实验室, 哈尔滨 150040;江苏食品药品职业技术学院, 江苏 淮安 223003;东北林业大学盐碱地生物资源环境研究中心, 东北油田盐碱植被恢复与重建教育部重点实验室, 哈尔滨 150040 |
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| 基金项目： | 国家林业局引进国际先进林业技术项目（2012-4-04）；黑龙江省留学归国基金项目（LC201004） |
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| 摘 要： | 目的:制备喜树碱衍生物CZ48缓释纳米粒并考察其体外释药特性。方法:以聚乳酸(PLA)为材料,采用W/O/W型乳化溶剂挥发法制备CZ48缓释纳米粒,通过透射电子显微镜观察纳米粒的微观形态,采用粒度分析仪测定粒径并考察该制剂的体外释药特性。结果:CZ48缓释纳米粒呈明显的球状结构,粒度(260.6±3.2)nm,载药量(11.8±1.29)%,包封率(88.7±2.55)%,体外释放可持续48 h,累积释放率达85%。结论:制备的CZ48缓释纳米粒包封率和载药量高,缓释效果明显,为该制剂的药代动力学研究提供数据支持。
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| 关 键 词： | CZ48 缓释纳米粒 聚乳酸 体外释放度 |
| 收稿时间： | 2014-02-18 |
Preparation and in vitro Release of CZ48 Sustained-release Nanoparticles |
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| LI Si-yang,KONG Qing-xin and WANG Yang. Preparation and in vitro Release of CZ48 Sustained-release Nanoparticles[J]. China Journal of Experimental Traditional Medical Formulae, 2014, 20(19): 5-7 |
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| Authors: | LI Si-yang KONG Qing-xin WANG Yang |
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| Affiliation: | Jiangsu Food & Pharmaceutical Science College, Huaian 223003, China;Alkali Soil Natural Environmental Science Center, Northeast Forestry University, Key Laboratory of Saline-alkali Vegetation Ecology Restoration in Oil Field, Ministry of Education, Harbin 150040, China;Jiangsu Food & Pharmaceutical Science College, Huaian 223003, China;Alkali Soil Natural Environmental Science Center, Northeast Forestry University, Key Laboratory of Saline-alkali Vegetation Ecology Restoration in Oil Field, Ministry of Education, Harbin 150040, China |
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| Abstract: | Objective: To prepare CZ48 sustained-release nanoparticles and investigate its in vitro release. Method: Using polylactic acid(PLA) as material,CZ48 sustained-release nanoparticles was prepared through W/O/W double emulsion technique,its micromorphology was observed by transmission electron microscope,particle size was determined by particle size analyzer and in vitro release was investigated. Result: CZ48 sustained-release nanoparticles showed obvious spherical structure with particle size of (260.6±3.2)nm,encapsulation efficiency of (88.7±2.55)% and drug-loading of (11.8±1.29)%,in vitro release studies showed that 85% of CZ48 was released from sustained-release nanoparticles in the first 48 h. Conclusion: These prepared CZ48 sustained-release nanoparticles are successfully prepared through W/O/W double emulsion technique with satisfactory encapsulation efficiency and drug-loading and obvious sustained-release,which provides data support for further research on pharmacokinetic. |
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| Keywords: | CZ48 sustained-release nanoparticles polylactic acid in vitro release |
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