99Tcm-phytate乳腺癌前哨淋巴结显像影响因素的研究

目的：分析99Tcm-phytate乳腺癌前哨淋巴结（SLN）显像时，患者年龄、肿瘤部位、大小及注射位置是否影响乳腺癌SLN显像的成功率。方法：手术前日在乳腺癌皮下注射0.2ml及肿瘤两侧（3、9点或6、12点）各注射99Tcm-phytate 0.1ml（122MBq/ml），注射示踪剂后5min、2h分别用单光子发射计算机断层仪（SPECT）行早期及延迟SLN显像。结果采用SPSS 11.5软件进行统计学处理，行χ2检验。结果：210例患者中，204例患者5min及?蛐或2h显像阳性，成功率为97.1%。乳腺癌所在的部位、大小、注射位置5min及2h显像均无统计学意义。年龄≤50岁和年龄＞50岁患者5min SLN显像阳性率分别为59.4%，44.7%（χ2＝4.03，P＜0.05）；2h SLN显像阳性率，年龄≤50岁和年龄＞50岁的分别为98.5%，90.7%（χ2＝4.49，P＜0.05）。结论：乳腺癌SLN显像的成功率不受乳腺癌所在的部位、大小、注射位置的影响，而年龄对其成功率有一定的影响。

The research of influence factor for breast sentinel lymphoscintigraphy with 99Tcm-phytate

Objective: Variable success rates for identifying axillary sentinel lymph node (SLN) in breast cancer patients using preoperative lymphoscintigraphy have been reported. We evaluated whether tumor location, size, method of interval and age affect its success in identifying SLN. Method: Preoperative breast lymphoscintigraphy was performed in consecutive breast cancer patients. Imaging at 5 minuties and 2 hours after peritumoral injection of ~99Tc~m-phytate. Chi-Square test for statistics was used with SSPS 11...