Role of ventral striatal dopamine D1 receptor in cigarette craving. |
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Authors: | Fumihiko Yasuno Miho Ota Kiyoshi Ando Tomomichi Ando Jun Maeda Tetsuya Ichimiya Akihiro Takano Talant K Doronbekov Yota Fujimura Shoko Nozaki Tetsuya Suhara |
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Affiliation: | Department of Molecular Neuroimaging, Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan. |
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Abstract: | BACKGROUND: Several theories of cigarette craving suggest that dopaminergic function in the ventral striatum plays an important role. The objective of this study was to determine correlations between craving-related brain activation and dopamine D1 receptor (D1R) binding in smokers. METHODS: Twelve smokers and 12 nonsmoking controls underwent [(15)O]H(2)O-positron emission tomography activation study and D1R-binding study using [(11)C]SCH 23390, and the correlations between receptor binding and cue-induced regional cerebral blood flow (rCBF) changes were assessed. Consecutive D1R-binding changes were examined during a period of 6 months of postsmoking abstinence in five smokers. RESULTS: Cue-induced activation was observed in the left ventral striatum including the nucleus accumbens in smokers. D1R binding in the ventral striatum showed a negative relationship with cue-induced craving and rCBF changes. D1R binding was significantly low in smokers, and there was a trend of increase after smoking abstinence. CONCLUSIONS: D1R binding and cue-induced rCBF changes in the ventral striatum suggest the important role of D1R in this region in cigarette craving. |
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Keywords: | Dopamine D1 receptor nicotine PET smoking tobacco ventral striatum |
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