侵袭性垂体腺瘤中Fascin蛋白、MMP-2和MMP-9的表达与研究

目的：垂体腺瘤侵袭性生长的机制还不清楚。本研究旨在检测肌动蛋白结合蛋白（Fascin）及基质金属蛋白酶-2（matrixmetallopmteinasesMMP-2）和基质金属蛋白酶-9（matrix metalloproteinasesMMP-9）在侵袭性垂体腺瘤中的表达水平，分析其与垂体腺瘤的生长侵袭性之间的可能关系。方法：免疫组织化学SP法检测三者在72例垂体腺瘤（侵袭性27例，非侵袭性45例）中的表达水平，统计学分析三者在垂体腺瘤中表达差异性．及与不同临床特征的表达相关性。结果：Fascin蛋白、MMP-2及MMP-9在侵袭性垂体腺瘤的表达水平高于非侵袭性垂体腺瘤（t=3．03，t=3．33，t=2．02，P〈0．05）。三者在垂体腺瘤中表达水平与患者性别无明显相关．与肿瘤有无分泌功能无明显相关，但与肿瘤大小有关铲值分别为8．53，11-31，12．46，P〈0．05）。结论：Fascin蛋白、MMP-2及MMP-9在侵袭性垂体腺瘤中高表达，提示三者可能与垂体腺瘤侵袭性生长密切相关．

Expressions of Fascin, MMP-2 and MMP-9 in Invasive Pituitary Adenomas

BACKGROUND ＆ OBJECTIVE： The mechanism underlying the invasion of pituitary adeno- mas is still unclear. The aim of this study was to determine the potential relationship between the invasiveness of adeno- mas and expressions of 3 proteins, aetin-binding protein （Fascin） and matrix metalloproteinases （MMP-2 and MMP-9）. METHODS： Immunohistochemistry assay was used to detect expressions of 3 proteins in 72 patients with pituitary ade- nomas （27 invasive adenomas and 45 non-invasive adenomas）. The differences of expressions of 3 proteins were statisti- cally analyzed. RESULTS： Expressions of Fascin, MMP-2 and MMP-9 in invasive group were higher than the non-inva- sive group （t=3.03, t=3.33, t=2.02, P〈 0.05）. Gender of patients and the function of endocrine did not have relationship with expressions of 3 proteins. But size of tumor did （X2 = 8.53, 11.31, 12.46, P〈 0.05）. CONCLUSION： Our study suggest that high expressions of Fasein, MMP-2 and MMP-9 may be indexes to the invasiveness of pituitary adenomas.