基于间断时间序列模型的辅助用药监管政策干预效果研究

辅助用药的不合理使用导致了医疗资源浪费、药物不良反应风险增加以及患者经济负担加重等诸多问题.为了促进合理用药、减轻患者用药经济负担,本研究聚焦于湖北省基层医疗卫生机构辅助用药的使用情况,以2018年8月为政策干预时点,回顾性收集干预前(2017年1月—2018年7月)和干预后(2018年8月—2019年10月)全省基层...

Intervention effects of supervision policy on adjuvant medicine based on interrupted time series analysis

The non-reasonable utilization of adjuvant medicines led to a waste of medical resources, an increase of adverse medicine reaction risks, heavy economic burden on patients and many other negative consequences. In order to promote rational utilization of medicines and lessen economic burden of medication faced by patients, this study focused on the use of adjuvant medicines in primary healthcare institutions located in Hubei province. Monthly procurement cost data were retrospectively collected, and emphasis was put on the periods of pre-intervention (in the period of January 2017-July 2018) and post-intervention (during the period from August 2018 to October 2019), respectively, with August 2018 as the intervention time point. Interrupted time series analysis was carried out to evaluate the intervention effects of the supervision policy on these medicines, so as to identify the types, attributes or dosage form of adjuvant medicines that require special supervision in the future. The results showed that supervision policy can restrict the procurement cost of adjuvant medicines to some extent, especially for essential medicines such as neurotrophic adjuvant medicines, including gangliosides and cerebroprotein hydrolysates or brain protein hydrolysates. However, regarding the active blood herbal injection in China, it is necessary to further develop clinical application guidelines, promote graded management, continuously carry out dynamic monitoring and strengthen transparency as well as relevant training to promote the rational utilization of adjuvant medicines nationwide.