朝鲜淫羊藿的化学成分

目的研究朝鲜淫羊藿(Epimedium koreanumNakai)中的化学成分。方法朝鲜淫羊藿干燥地上部分用水回流提取后,经大孔吸附树脂柱色谱分离,用水及不同体积分数的乙醇洗脱;50%乙醇洗脱部分的浸膏用硅胶柱色谱分离,用氯仿甲醇梯度洗脱,得到的第5、8、10流份用羟丙基葡聚糖凝胶柱色谱分离、十八烷基键合硅胶柱色谱分离、制备型HPLC纯化后得到化合物1~8;根据化合物的理化性质和核磁共振氢谱、碳谱数据对所得化合物进行结构鉴定,分析确定化学结构。结果从朝鲜淫羊藿水提取物中分离得到8个化合物:淫羊藿苷(icariin,1)、宝藿苷Ⅰ(baohuosideⅠ,2)、箭藿苷B(sagittatoside B,3)、宝藿苷Ⅱ(baohuosideⅡ,4)a、stragalin(5)、3,5,7三羟基4′甲氧基8异戊烯基黄酮3OαL鼠李吡喃糖基(1→2)α鼠李吡喃糖苷(6)、1,2,3,4 tetrahy-dro 3,7 dihydroxy 1(4 hydroxy 3 methoxyphenyl)6 methoxy 2,3 naphthalenedimethanol(7)、朝藿定C(epimedin C,8)。结论化合物7为首次从该属植物中分离得到,化合物8为首次从该种植物中分离得到。

Chemical constituents from Epimedium koreanum Nakai

Objective To study the chemical constituents from Epimedium koreanum Nakai.Methods The constituents in the water extract of Epimedium koreanum Nakai were isolated by the combination of silica gel,Sephadex LH-20 and ODS chromatography and their structures were identified by spectral methods.Results Eight known compounds were isolated from Epimedium koreanum Nakai.Their structures were identified as icariin(1),baohuoside-Ⅰ(2),sagittatoside B(3),baohuoside-Ⅱ(4),astragalin(5),3,5,7-trihydroxy-4′-methoxy8-prenylflavone-3-O-α-L-rhamnopyranosyl-(1→2)-α-L-rhamnopyranoside(6),1,2,3,4-tetrahydro-3,7-dihydroxy -1-(4-hydroxy-3-methoxyphenyl)-6-methoxy-2,3-Naphthalenedimethanol(7) and epimedin C(8).Conclusions Compound 7 was isolated from the Epimedium genus for the first time and compound 8 was isolated from Epimedium koreanum for the first time.