| 离子选择性电极法测定卡托普利片含量 |
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| 引用本文： | 程会云,陈晓红,刘占厚,朱俊博,陈湘宏.离子选择性电极法测定卡托普利片含量[J].中国当代医药,2009,16(5):33-34. |
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| 作者姓名： | 程会云 陈晓红 刘占厚 朱俊博 陈湘宏 |
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| 作者单位： | 青海大学医学院药学系,青海西宁,810001 |
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| 摘 要： | 目的：建立离子选择性电极法测定卡托普利片含量的新方法。方法：卡托普利结构含有-SH，呈酸性，与碱作用生成RS-硫离子选择性电极对其产生响应。结果：电极响应的电位值与-lgRS-]符合能斯特方程。能斯特响应范围为1．0×10^-6～1．0×10^-2mol／L（r=0．9998），平均回收率为99．4％，RSD=0．29％（n=6）。结论：本法设备仪器简单，分析快速，专属性强。
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| 关 键 词： | 离子选择性电极 卡托普利片 含量 |
Determination of the content in Captopril Tablets with ion selective electrode |
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| Authors: | CHENG Hui-Yun CHEN Xiao-hong LIU Zhan-hou ZHU Jun-bo CHEN Xiang-hong |
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| Institution: | (Department of Pharmaceutical Sciences School of medicines Qinghai University, Xining 810001, China) |
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| Abstract: | Objective： A new method was established for the determination of Captopril with ion selective electrode. Methods： Based on the thiohydroxy group （-SH） in Captopril can rect with base and produce RS-,Results： The linear relationship between E and - lgRS-] was held in the range of 1.0×10^-6～1.0×10^-2mol/L（r=0.9998）.The average recovery was 99.4% ,RSD=0.29%（n=6）. Conclusion：This method is simple,convenient,specific and is suitable for the quality control of Captopril tablets. |
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| Keywords: | Ionselective electrode Captopril tablets Content |
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