| 双黄连分散片的研制及质量评价 |
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| 引用本文： | 郭新红,张楠,张振中.双黄连分散片的研制及质量评价[J].郑州大学学报(医学版),2005,40(6):1157-1159. |
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| 作者姓名： | 郭新红 张楠 张振中 |
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| 作者单位： | 郑州大学药学院,郑州,450052;郑州大学药学院,郑州,450052;郑州大学药学院,郑州,450052 |
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| 摘 要： | 目的：研制双黄连分散片.方法：选用不同比例的明胶、甘露醇、甜菊苷和糖精钠对双黄连进行矫味试验,然后采用正交试验以崩解时限为指标筛选出分散片最优处方,并对其进行了溶出度测定.结果：当m（药物）：m（明胶）：m（甘露醇）=1：0.7：1时,双黄连味甜,且颗粒疏松.分散片的最优处方为：w（PVPP）为6.2%,w（MCC）为24%,w（硬脂酸镁）为0.5%,3 min时黄芩苷的累积溶出度达85.89%.结论：本研究制得的双黄连分散片处方合理,溶出迅速,而且味甜,抗湿性能好,极大提高患者用药顺应性.
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| 关 键 词： | 双黄连 矫味 分散片 正交设计 |
| 收稿时间： | 2004-07-01 |
| 修稿时间： | 2004年7月1日 |
Study on formulation of dispersible tablets of shuanghuanglian |
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| GUO Xinhong,ZHANG Nan,ZHANG Zhenzhong.Study on formulation of dispersible tablets of shuanghuanglian[J].Journal of Zhengzhou University: Med Sci,2005,40(6):1157-1159. |
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| Authors: | GUO Xinhong ZHANG Nan ZHANG Zhenzhong |
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| Institution: | College of Pharmacology, Zhengzhou University, Zhengzhou 450052 |
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| Abstract: | Aim: To prepare dispersible tablets of Shuanghuanglian. Methods: To select gelatin and mannitol as corrective agents to hide bitter taste of Shuanghuanglian. Experiments were conducted by orthogonal design to select the optimum formulation.Results: When the proportion of Shuanghuanglian,gelatin and mannitol was 1 :0.7 :1,the bitter taste was hiden.The optimum dispersible tablets compositions were: PVPP 6.2%,MCC 24% and magnesium 0.5%.The accumulated dissolution at 3 min reached 85.89%. Conclusion: The preparation complies with the requirements of Chinese Pharmacopoeia 2000. |
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| Keywords: | Shuanghuanglian hide bitter taste dispersible tablet orthogonal design |
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