Derivative 11 marker chromosome in bladder carcinoma |
| |
Authors: | R Vanni D Peretti R M Scarpa E Usai |
| |
Institution: | 1. Istituto di Biologia Generale, Facoltà di Medicina e Chirurgia, Università di Cagliari, Italy.;2. Istituto di Clinica Urologica, Facoltà di Medicina e Chirurgia, Università di Cagliari, Italy. |
| |
Abstract: | Cytogenetic studies on bladder carcinomas from two patients were carried out on preparations obtained by a direct method. The chromosome mode was 49 and 55, respectively. Several karyotypic changes were found in the tumors. Moreover, the analysis of Q-banded chromosomes revealed the presence in both cases of a chromosome 11p+. These rearranged chromosomes showed a very similar banding pattern. The finding of a der(11) chromosome marker in two patients is intriguing, and suggests the possibility of nonrandom chromosome changes in bladder carcinoma, as already found in other kinds of tumors. The occurrence of chromosome #11 aberrations in tumors of the urinary tract is discussed in connection with the current theories on oncogenesis. |
| |
Keywords: | Address requests for reprints to Dr Roberta Vanni Instituto di Biologia Generale Facoltà di Medicina e Chirurgia Università degli Studi Via Ospedale 121 09100 Cagliari Italy |
本文献已被 ScienceDirect 等数据库收录! |
|