双核素结肠显像检测结肠运动功能

目的 建立一种新的、无创性的放射性核素定量检测结肠运动功能的方法。方法 正常对照者３２例，便秘患者２４例。将Ｎａ＾１３１Ｉ密封于在胃肠道内不被消化吸收的聚氯乙烯胶囊内，受检者同时口服Ｎａ＾１３１Ｉ胶囊及＾９９Ｔｃ－硫胶体，然后定时静态双核素采集，并计算图形中心（ＧＣ）值。结果 （１）＾９９Ｔｃ－硫胶体能清晰显示结肠轮廓，对Ｎａ＾１３１Ｉ胶囊进行准确体内定位；（２）正常对照组其口盲，结肠及全胃肠道通

A study of the colonic transit function by dual radionuclide colon scintigraphy

Objective To establish a new, simple and noninvasive method which can quantitatively analyze the colonic transit function by dual radionuclide colon scintigraphy Methods 24 patients with constipation and 32 normal controls were studied Na131I was sealed into capsule made by polyvinlychloride which can not be digested and absorbed in gastrointestinal tract Patients KG*4and normal volunteers swallow 131I 6capsules and drink 99 Tcm labeled surful colloid solution at the same time The static image was acquired at the regular time, then calculate the Geometric Center values (GC) Results The capsules can be clearly located through the colonic contour shown by 99 Tcm labeled surful colloid when it reached the large bowel The transitting time from mouth to cecum, through colon and through whole gastrointestinal in normal people were (661194), (36611051) and (42721002) h, respectively, in constipation group were (803363), (65502840) and (74052817) h, respectively There was no significant difference ( P >005) in two groups compared with each other But the transitting time through colon and whole gastrointestinal in constipation was slower than that in normal people, with significant difference ( P <001) Through examination the colonic transit abnormality can be divided into three patterns: whole colon transit delay, rightcolon transit delay and leftcolon transit delay Conclusions This method is a simple, physiologic and quantitative in evaluating the colonic transit, it can also stage the colonic dyskinesia of the patients