| 35S标记SZ39导向治疗胶质瘤的实验研究 |
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| 引用本文： | 兰青,黄强,庄道玲. 35S标记SZ39导向治疗胶质瘤的实验研究[J]. 中华核医学杂志, 1999, 19(1): 19-21 |
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| 作者姓名： | 兰青 黄强 庄道玲 |
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| 作者单位： | 苏州医学院附属第二医院脑外科，中国科学院上海原子核研究所 |
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| 摘 要： | 目的 制备纯β射线放射免疫治疗制剂＾３５Ｓ标记单克隆抗体（ＭＡｂ）ＳＺ３９，并证实其对胶质瘤的特异杀伤作用，方法 ＾３５Ｓ以碳二亚胺法标记ＳＺ３９，采用ＭＴＴ法，以人脑胶质瘤细胞系ＳＨＧ４４为靶细胞，检测＾３５Ｓ－ＳＺ３９及其对照组＾３５Ｓ－ｎＩｇＧ，＾３５Ｓ和ＳＺ３９，＾３５Ｓ持续作用组的细胞杀伤率，求得５０％，细胞抑制浓度，以荷瘤鼠为对象，以＾３５Ｓ－ｎＩｇＧ，及ＰＢＳ为对照组，根据公式求得＾
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| 关 键 词： | 神经胶质瘤 硫35标记 SZ39 导向疗法 |
An experimental study of targeting therapy with 35 S SZ39 against glioma |
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| LAN Qing ,HUANG Qiang,ZHUANG Daoling,et al The Second Affiliated Hospital,Suzhou Medical College,Suzhou. An experimental study of targeting therapy with 35 S SZ39 against glioma[J]. Chinese Journal of Nuclear Medicine, 1999, 19(1): 19-21 |
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| Authors: | LAN Qing HUANG Qiang ZHUANG Daoling et al The Second Affiliated Hospital Suzhou Medical College Suzhou |
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| Affiliation: | LAN Qing *,HUANG Qiang,ZHUANG Daoling,et al *The Second Affiliated Hospital,Suzhou Medical College,Suzhou 215004 |
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| Abstract: | |
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| Keywords: | Glioma Antibodies monoclonal Antibodies neoplasm Sulfur radioisotopes Radioimmunotherapy |
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