| 慢性充血性心力衰竭患者sFas及TNF观察 |
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| 引用本文： | 秦明照,王国宏,翟艳玲,田海玲. 慢性充血性心力衰竭患者sFas及TNF观察[J]. 首都医科大学学报, 2000, 21(4): 307-308 |
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| 作者姓名： | 秦明照 王国宏 翟艳玲 田海玲 |
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| 作者单位： | 首都医科大学附属北京同仁医院心内科 |
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| 摘 要： | 为探讨慢性充血性心力衰竭 (CHF)患者血清可溶性factorassociatedsuicide (Fas)、肿瘤坏死因子 (TNF)水平及其在不同心衰程度时的变化 ,应用酶联免疫法测定了 30例冠心病CHF患者的sFas和TNF。结果 :心衰组sFas为 ( 7.83± 5.66) μg/L ,TNF为 ( 5.58±1 .84 ) μg/L ,均高于正常对照组 (P <0 .0 5)。心功能Ⅳ级组sFas虽高于心功能Ⅲ级组 ,但 2组间无显著性差异。提示 :慢性心功能不全患者血清sFas、TNF均升高 ,其可能在CHF发病中起作用
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| 关 键 词： | 慢性充血性心力衰竭 细胞凋亡 可溶性脂肪酸合成酶 肿瘤坏死因子 |
| 收稿时间： | 2000-04-06 |
| 修稿时间： | 2000-04-06 |
Observation of sFas and TNF in Patients with Chronic Heart Failure |
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| Qin Mingzhao,Wang Guohong,Zhai Yanling,Tian Hailing. Observation of sFas and TNF in Patients with Chronic Heart Failure[J]. Journal of Capital Medical University, 2000, 21(4): 307-308 |
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| Authors: | Qin Mingzhao Wang Guohong Zhai Yanling Tian Hailing |
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| Affiliation: | Department of Internal Medicine, Beijing Tongren Hospital, Affiliate of Capital University of Medical Sciences |
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| Abstract: | To examine serum levels of soluble Fas(sFas) and tumor necrosis factor(TNF) in chronic heart failure and its relation to heart functional classes, 30 patients with coronary heart disease and chronic heart failure were observed. The study included 19 in NYHA heart functional Ⅲ, 11 in functional Ⅳ and 24 at the age matching normal control subjects. Serum sFas and TNF were measured by enzyme linked immunosorbent assay. Results: sFas(7.83±5.66) μg/L and TNF(5.58±1.84) μg/L were increased in CHF than that in the control group, and sFas increased with severity of heart funtional classification. The increase of sFas and TNF may play an important role in the pathogenesis of CHF. |
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| Keywords: | CHF apoptosis sFas TNF |
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