免疫无标记型急性淋巴细胞白血病的临床特点

目的:了解免疫无标记型急性淋巴细胞白血病(ALL)的临床特点。方法:对447例形态学上诊断为ALL的病例,取其外周血或骨髓,分离出单个核细胞,应用APAAP法作免疫表型分析,对免疫无标记型病例的临床特点、化疗疗效及预后进行了观察。结果:42例患者未表达任何系统性分化标记,或仅表达CD38、HLA-DR或CD9等非系限性抗原。与分化型ALL相比,免疫无标记型ALL肝、脾、淋巴结肿大及纵隔肿块发生率与白细胞数量均较高,化疗完全缓解率(CR)较低(P<0.05),存活期较短(P<0.01)。结论:免疫无标记型ALL有其临床上的特殊性,预后较差。

Clinical characteristics ot the patients with non-immunophenotypic acute lymphoblastic leukemia

Objective:To observe the clinical characteristics of the patients with non-immunophenotypic acute lymphoblastic leukemia(ALL).Methods:Blood or bone marrow samples were taken from447patients who had been diagnosed as ALL by morphology,and APAAP staining method was used for their mononucleur cells(MNCs)immunophenotypic analysis,and the clinical characteristics,chemotherapy results and the prognosis of these ALL patients were also observed.Results:42cases had no systemic immunophenotype,or only expressed CD38,HLA-DR or CD9antigens which were non-systemic phenotypes.In contrast with the differentiated ALL cases,they were move inclined to develop hepatomegaly,splenomegaly,lymphnode enlargement,vertical diaphragm mass and hyper leukecytes,with lower CR rate(P<0.05)and shorter survival period(P<0.01).Conclusion:The non-immunophenotypic ALL cases have their clinical specialties and might have poor prognosis.