依达拉奉联合小牛血去蛋白提取物治疗脑梗死的研究

目的 观察依达拉奉联合小牛血去蛋白提取物治疗急性脑梗死的疗效.方法 将270例急性脑梗死患者随机分为3组：A组给予依达拉奉、小牛血去蛋白提取物及常规治疗,B组给予依达拉奉及常规治疗,C组给予常规治疗.比较3组患者治疗14天前后的美国国立卫生研究院卒中量表（NIHSS）评分及治疗后3个月的日常生活活动能力（ADL）及改良Rankin量表（mRS）评分.结果 3组患者治疗前NIHSS评分比较,差异无统计学意义（P＞0.05）.治疗14天后的NIHSS评分比较,差异有统计学意义（P＜0.05）.3组患者治疗14天后的有效率比较,A组（86.67％）最高,C组（46.67％）最低（P＜0.01）.治疗后3个月3组患者的ADL、mRS评分比较,A组ADL评分（65.00±29.20）最高,mRS评分（2.40±1.28）最低;C组ADL评分（46.72±27.63）最低,mRS评分（3.72±1.24）最高（P＜0.05）,提示A组预后最好,C组预后最差.结论 依达拉奉联合小牛血去蛋白提取物能保护脑细胞,有效改善预后,是治疗急性脑梗死的一种有效方法.

Study on edaravone combined with deproteinized hemoderivative of calf blood in the treatment of cerebral infarction

Objective To observe curative effect of edaravone combined with deproteinized hemoderivative of calf blood in the treatment of acute cerebral infarction.Methods 270 cases of acute cerebral infarction patients divided into three groups randomly.Group A was treated with edaravone,dproteinized hemoderivative of calf blood and conventional treatment.Group B was treated with edaravone and conventional treatment.Group C was treated with conventional treatment.The NIHSS scores were compared between the three groups before treatment and after treatment of 14 days.The ADL and mRS scores were compared between the three groups for 3 months after treatment.Results The three groups before treatment NIHSS scores comparison,the difference was not statistically significant （P 〉 0.05）.The three groups of treatment after 14 days of NIHSS scores comparison,the difference was statistically significant（P 〈0.05）.The three groups of treatment after 14 days of the effective rate comparison,group A（86.67%） was the highest,group C（46.67%） was the lowest（P 〈0.01）.The ADL and mRS scores were compared between the three groups for 3 months after treatment,the ADL score of group A was the highest（65.00 ± 29.20）,mRS score was the lowest（2.40 ± 1.28）,The ADL score of group C was the lowest（46.72 ± 27.63）,mRS score was the highest （3.72 ± 1.24,P 〈 0.05）.The prognosis of group A was the best,group C was the worst prognosis.Conclusion Edaravone combined with deproteinized hemoderivative of calf blood can protect brain cells,effectively improve the prognosis.It is an effective method in the treatment of acute cerebral infarction.