兰索拉唑配合阿莫西林克拉维酸钾治疗上消化道溃疡的临床疗效分析

目的分析兰索拉唑配合阿莫西林克拉维酸钾治疗上消化道溃疡的临床疗效,为临床工作提供借鉴资料。方法选择该院2012年2月—2013年1月收治的112例上消化道溃疡患者作为研究对象,对照组52例患者采用常规三联疗法、用药为奥美拉唑、阿莫西林、克拉霉素,观察组60例患者采用兰索拉唑配合阿莫西林克拉维酸钾治疗,比较两组药物的临床应用情况。结果观察组总有效率为98.3%,明显高于对照组的86.5%,两组间差异有统计学意义(P<0.05);观察组的反酸、烧心、腹胀嗳气症状消失时间分别为(5.6±1.1)、(6.1±2.0)、(7.9±1.8)d,均明显短于对照组的(7.8±1.6)、(7.9±1.4)、(9.0±2.3)d,两组间差异有统计学意义(P<0.05);两组均无严重不良反应发生。结论兰索拉唑配合阿莫西林克拉维酸钾治疗上消化道溃疡的临床疗效更好,且患者康复快,用药安全性可靠,是值得推广应用的用药方案。

Analysis of clinical efficacy of lansoprazole combined with amoxicillin and clavulanate potassium treatment of peptic ulcer

Objective To analyze the clinical efficacy of lansoprazole combined with amoxicillin and clavulanate potassium treatment of peptic ulcer, provide the reference for the clinical work. Methods In our hospital from 2012 February to 2013 January were treated 112 cases of peptic ulcer patients as the research object, the control group of 52 cases treated with conventional triple therapy, omeprazole, amoxicillin, clarithromycin treatment, the observation group of 60 patients were treated with lansoprazole with A Mo Westwood and clavulanate potassium treatment, compared two groups of drugs in clinical application. Results The total effective rate in the observation group was 98.3%, significantly higher than 86.5% in the control group, there was significant difference between the two groups （P 〈 0.05） ; observation group of acid reflux, heartburn, bloating, belching symptoms disappear time is respectively （5.6 ± 1.1）, （6.1 ± 2）, （7.9 ± 1.8） d, were significantly shorter than in control group（7.8±1.6）, （7.9±1.4）, （9±2.3）d, there was significant difference between the two groups （P 〈 0.05） ; there were no serious adverse reactions in two groups. Conclusion Clinical efficacy of lansoprazole with better results of amoxicillin and clavulanate potassium treatment of peptic ulcer, and the patients can recover soon, safety and reliable, is worthy of popularization and application of medication.