| 血管内皮生长因子和Notch信号通路与肿瘤血管生成 |
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| 引用本文： | 钱亚云.血管内皮生长因子和Notch信号通路与肿瘤血管生成[J].国际肿瘤学杂志,2009,36(11). |
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| 作者姓名： | 钱亚云 |
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| 作者单位： | 扬州大学医学院中西医结合临床医学系,225000 |
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| 基金项目： | 国家中医药管理局科学技术研究专项项目，江苏省普通高校研究生科研创新计划项目 |
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| 摘 要： | 血管内皮生长因子(VEGF)和Notch信号通路是血管发育及肿瘤血管生成的重要机制.阻断VEGF可抑制肿瘤生长和血管生成.Notch能抑制内皮形成尖端细胞,减少血管生成.实验证明,两条通路相互作用,联合阻断VEGF和Notch信号通路可协同抑制肿瘤生长.对VEGF和Notch通路的研究,将为肿瘤临床治疗提供新的方法.
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| 关 键 词： | 信号传导 肿瘤 新生血管化 病理性 |
VEGF and Notch pathways in tumor angiogenesis |
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| QIAN Ya-yun.VEGF and Notch pathways in tumor angiogenesis[J].Journal of International Oncology,2009,36(11). |
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| Authors: | QIAN Ya-yun |
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| Abstract: | VEGF and Notch signaling pathways are important mechanisms in regulation of embryonic vascular development and tumor angiogenesis.Blockade of the VEGF pathway effectively inhibits tumor anglo- genesis and growth.Recent findings indicate that Notch signaling decreases angiogenesis by suppressing endo-thelial tip cell formation.Combination therapy by blocking Notch and VEGF pathways synergistically inhibits tumor growth in preclinical models.Thus,targeting VEGF and Notch pathways may lead to new therapies for clinical application. |
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| Keywords: | Signal transduction Neoplasms Neovascularization pathologic |
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