| 雷公藤甲素抗类风湿性关节炎机制研究进展 |
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| 引用本文： | 刘春芳,林娜.雷公藤甲素抗类风湿性关节炎机制研究进展[J].中国中药杂志,2006,31(19):1575-1579. |
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| 作者姓名： | 刘春芳 林娜 |
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| 作者单位： | 中国中医科学院,中药研究所,北京,100700 |
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| 基金项目： | 国家自然科学基金;国家中医药管理局资助项目 |
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| 摘 要： | 对雷公藤甲素治疗类风湿性关节炎（RA）的分子机制研究进行了综述。雷公藤甲素具有免疫抑制、抗炎反应、诱导细胞凋亡、抑制血管增生、保护软骨以及基因调控等多方面的作用,是一种有良好应用前景的新型免疫抑制剂。
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| 关 键 词： | 雷公藤甲素 类风湿性关节炎 作用机制 |
| 文章编号： | 1001-5302（2006）19-1575-05 |
| 收稿时间： | 2/9/2006 12:00:00 AM |
| 修稿时间： | 2006-02-09 |
Progress in research on mechanisms of anti-rheumatoid arthritis of triptolide |
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| LIU Chun-fang;LIN Na.Progress in research on mechanisms of anti-rheumatoid arthritis of triptolide[J].China Journal of Chinese Materia Medica,2006,31(19):1575-1579. |
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| Authors: | LIU Chun-fang;LIN Na |
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| Institution: | Instititute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China |
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| Abstract: | Extracts of Tripterygium wilfordii are effective in traditional Chinese medicine for treatment of rheumatoid arthritis (RA). Triptolide, a diterpenoid triepoxide purified from TWHF, has been identified as the major component of TWHF and might account for its therapeutic effects. To make for the clinical reasonable application and further development of triptolide, in this review was introduced the recent ten-years progress in mechanisms of anti-RA of it, including immunosuppression, anti-inflammation, inducing cell apoptosis, inhibiting vascular proliferation, protecting article cartilage and gene regulation. Triptolide is a potent immunosuppressant. |
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| Keywords: | triptolide rheumatoid arthritis mechanism |
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