Antiplaque and antigingivitis effectiveness of a hexetidine mouthwash |
| |
Authors: | Sharma N C Galustians H J Qaqish J Charles C H Vincent J W McGuire J A |
| |
Institution: | BioSci Research Canada Ltd., Kitimat Road, Mississauga, Ontario, Canada Pfizer Inc, Morris Plains, NJ, USA. |
| |
Abstract: | OBJECTIVE: To assess the antiplaque/antigingivitis efficacy of a hexetidine-containing mouthwash. METHODS: This examiner-blind, parallel group, controlled clinical study examined the effectiveness of a hexetidine (0.1%) mouthwash both in inhibiting the development of supragingival plaque and in reducing gingivitis. One hundred and thirty-four adult subjects completed the 2-week experimental gingivitis model study. Following baseline examinations, which included plaque index, modified gingival index and gingival bleeding index, subjects received a full dental prophylaxis. Subjects were randomly assigned to one of three mouthwashes (hexetidine 0.1%, chlorhexidine 0.12% (positive control) or a 5% hydroalcohol negative control) and commenced three times daily supervised rinsing as their sole method of oral hygiene. All indices were rescored after 2 weeks. RESULTS: Compared to the negative control group, the hexetidine group demonstrated a statistically significant inhibition and reduction of supragingival plaque and gingival inflammation with reductions of 6.3%, 33.5% and 56% for gingivitis, plaque and gingival bleeding, respectively. The results of the chlorhexidine group were used to validate the study. CONCLUSION: The study confirms the efficacy of a hexetidine rinse in reducing supragingival plaque and gingival inflammation. |
| |
Keywords: | hexetidine plaque gingivitis mouthwash prophylaxis |
本文献已被 PubMed 等数据库收录! |
|