| 肿瘤相关蛋白分子核转运机制研究进展 |
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| 作者姓名： | 张艺新 戴蓓英 杨勇 陈真 |
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| 作者单位： | 中国药科大学药学院,江苏 南京211198;中国药科大学药物科学研究院,江苏 南京211198;中国药科大学基础医学与临床药学学院,江苏 南京211198 |
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| 基金项目： | 国家自然科学基金（No.82002971） |
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| 摘 要： | 信号分子的核转运是多种信号传导通路的基础。肿瘤的发生和发展常与多种信号蛋白异常的亚细胞定位相关，因此阐明肿瘤相关蛋白的核转运机制对于研究肿瘤的发病机制和开发新的疗法至关重要。本文介绍了核转运系统的基本组成，并对多种重要的肿瘤相关蛋白的核转运机制进行综述。
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| 关 键 词： | 肿瘤相关蛋白分子 核转运 核转运系统 分子机制 |
Research progress on nuclear transport mechanism of tumor-associated proteins |
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| Authors: | ZHANG Yixin DAI Peiying YANG Yong CHEN Zhen |
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| Abstract: | The nuclear transport of signal molecules is the basis of many signal transduction pathways. The occurrence and development of tumors are often related to the abnormal subcellular localization of a variety of signal proteins. Therefore, elucidating the nuclear transport mechanism of tumor-related proteins is essential for studying the pathogenesis of tumors and developing new therapies. This article introduces the basic components of the nuclear transport system and reviews the nuclear transport mechanisms of many important tumor-related proteins. |
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| Keywords: | Tumor-associated protein Nuclear transport Nuclear transport system Molecular mechanism |
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