3006例原发性高血压患者中医证型与生化指标的相关性研究

目的 观察原发性高血压患者中医证型分布规律与临床生化指标的关系,为深入探讨其病因病机和高血压辨证客观化提供依据.方法 按纳入标准选择2013年1月1日—2018年6月30日北京市东城区38个社区卫生中心诊治的原发性高血压患者3006例,充分收集患者中医四诊信息,对其进行辨证分型,并进行统计分析.结果 高血压各证型分布比...

Correlation between TCM syndromes and biochemical indexes in 3006 patients with essential hypertension

Objective It is to observe the relationship between the distribution of TCM syndromes and clinical biochemical indexes in patients with essential hypertension,so as to provide evidences for in-depth discussion of the etiology,pathogenesis and objectification of hypertension syndrome differentiation.Methods 3006 patients with essential hypertension were selected according to the inclusion criteria,and their information of the four diagnosis of TCM was fully collected for syndrome differentiation and statistical analysis.Results The distribution proportion of various syndromes of hypertension from high to low were as follows:Yin deficiency and Yang hyperactivity syndrome>liver fire flaming syndrome>Qi and blood deficiency syndrome>excessive accumulation of phlegm-dampness syndrome>blood stasis obstructing collaterals syndrome>deficiency of Yin and Yang syndrome>deficiency of kidney essence syndrome.The sex ratio of all syndromes was significantly different.There was no statistically significant difference in the blood glucose levels of patients of each syndrome type(P>0.05).The TC and UA levels of excessive accumulation of phlegm-dampness syndrome were higher than those of the other syndromes,the differences were significant compared with Yin deficiency and Yang hyperactivity syndrome,Qi and blood deficiency syndrome and the HDL level was significantly lower than those of the other syndromes,the differences were significant except deficiency of kidney essence syndrome(P<0.05).The TG level of liver fire flaming syndrome was higher than that of the other syndrome types,and the difference was statistically significant(P<0.05).The HCY level of the blood stasis obstructing collaterals syndrome was the highest,the differences were significant compared with Yin deficiency and Yang hyperactivity syndrome,liver fire flaming syndrome,Qi and blood deficienly syndrome,excessive accumulation of phlegm-dampness syndrome.Conclusion Yin deficiency and Yang hyperactivity syndrome accounts for the highest proportion in patients with hypertension.The level of homocysteine was higher than normal in patients with various syndromes of hypertension.The degree of dyslipidemia in patients with excessive accumulation of phlegm and dampness was higher than other syndroms.Uric acid was the highest in patients with excessive accumulation of phlegm and dampness.