| 免疫检查点抑制剂相关甲状腺毒症 |
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| 作者单位： | ;1.中国医学科学院北京协和医学院北京协和医院内分泌科国家卫健委内分泌重点实验室;2.中国医学科学院北京协和医学院北京协和医院呼吸与危重症医学科 |
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| 摘 要： | 免疫检查点抑制剂(immune checkpoint inhibitors, ICIs)是近年来恶性肿瘤治疗领域的一项重大突破。其通过针对T细胞的调节作用,增强抗肿瘤免疫反应,改善恶性肿瘤患者的预后,延长患者生存期,现已获批用于治疗多种肿瘤,但ICIs在应用过程中产生的甲状腺毒症是不容忽视的临床问题。本文对ICIs相关甲状腺毒症的发生机制、临床表现、处理对策等进行综述。
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| 关 键 词： | 免疫检查点抑制剂 免疫相关不良反应 甲状腺毒症 |
Thyrotoxicosis Related to Immune Checkpoint Inhibitors |
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| Affiliation: | ,Department of Endocrinology,Key Laboratory of Endocrinology,National Health Commission of the People's Republic of China,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences & Peking Union Medical College,Department of Respiratory and Critical Care Medicine,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences & Peking Union Medical College |
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| Abstract: | Immune checkpoint inhibitors(ICIs) have come out in recent years as a breakthrough of the treatments for malignant tumors by regulating T cells with the purpose of enhancing their anti-tumor response, which can improve prognosis and increase survival. However, thyrotoxicosis caused by ICIs has become a clinical problem that cannot be ignored. This review summarizes the pathogenic mechanisms, clinical manifesta-tions, and treatments of ICIs associated thyrotoxicosis. |
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| Keywords: | immune checkpoint inhibitors immune-related adverse events thyrotoxicosis |
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