Human immunodeficiency virus (HIV) antibody avidity testing to identify recent infection in newly diagnosed HIV type 1 (HIV-1)-seropositive persons infected with diverse HIV-1 subtypes |
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| Authors: | Chawla A Murphy G Donnelly C Booth C L Johnson M Parry J V Phillips A Geretti A M |
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| Affiliation: | Department of Virology, Royal Free Hospital, Royal Free and University College Medical School, London, UK. |
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| Abstract: | A guanidine-based antibody avidity assay for the identification of recently acquired human immunodeficiency virus type 1 (HIV-1) infection was evaluated. The kinetics of maturation of antibody avidity were determined prospectively in 23 persons undergoing acute seroconversion followed for up to 1,075 days. Avidity indices (AI) of
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