1207例门诊泌尿生殖道感染者性病病原学检测分析

目的：调查医院性病和妇产科门诊患者沙眼衣原体（CT）、解脲支原体（UU）、淋球菌（NG）所致的感染情况,确定性传播疾病（STD）防治的高危人群。方法：采用荧光定量PCR方法对荆州市中心医院2006年1月～2007年10月性病门诊和妇产科门诊就诊的1 207例STD疑似患者留取的分泌物CT、UU、NG进行检测,比较不同性别、不同年龄以及其混合感染的情况。结果：3种性病病原体总阳性率为48.30%,女性（56.28%）明显高于男性（29.75%）（P〈0.01）,男性CT-DNA阳性率明显高于女性（P〈0.05）,UU-DNA阳性率明显低于女性（P〈0.01）;女性CT＋UU、UU＋NG、CT＋UU＋NG 3种病原体的混合感染率均高于男性,但差异无统计学意义（P〉0.05）;3种病原体总感染率以18～50岁年龄组较高（P〈0.01）,各年龄段NG-DNA感染差异无统计学意义（P〉0.05）,CT-DNA、UU-DNA感染差异有统计学意义（P〈0.05）。结论：荆州市中心医院STD疑似患者CT、UU、NG等3种病原体的感染率较高,总阳性检出率为48.30%,混合感染率较高,感染年龄以18～40岁者居多,女性较为严重.

Detection of pathogens causing sexually transmitted diseases of the urogenital system in 1207 cases

Objective: To explore pathogen infection of chlamydia trachomatis(CT),ureaplasma urealyticum(UU),neisseria gonorrhoeae(NG) in sexually transmitted diseases(STD) and maternity clinics outpatients.Confirm the high risk population of STD prevention and cure.Methods: The CT,UU,NG of secretion in 1207 suspected STD cases in STD and maternity clinics from January 2006 to October 2007 were detected by the means of fluorescent quantitative PCR.Results:Total positive rate was 48.30%,positive rate in female was higher than that in male(56.28% vs 29.75%,P<0.01),positive rate of CT-DNA in male was higher than that in female(P<0.05),positive rate of UU-DNA in male was lower than that in female(P<0.01);Mixture infection rates of 3 pathogens(CT+UU,UU+NG,CT+UU+NG) in female were much more than that in male,while had no statistics significance(P>0.05) between them.Total infection rate of 3 pathogens in 18-50 age group was higher than that of others(P<0.01).There were statistics significance among each aged group on infection of CT-DNA and UU-DNA(P<0.05).Conclusion:Infection rates of CT,UU,NG pathogens in suspected STD cases from Jingzhou Centre Hospital are relatively higher.Total positive rate is 48.30%,mostly are cases of mixture infection,most of the infected cases are at age from 18 to 40;female are more severely.