Transitional cell carcinoma expresses high levels of Fas ligand in vivo |
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Authors: | Lee S H Lee J Y Park W S Kim S Y Jang J J Yoo N J |
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Institution: | Department of Pathology and Cancer Research Institute, Catholic University College of Medicine, Seoul, Korea. |
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Abstract: | OBJECTIVE: To characterize the Fas-Fas ligand system, a main apoptotic pathway, in transitional cell carcinoma (TCC) of the urinary bladder, by analysing the expression of Fas and Fas ligand (FasL) in TCC samples. MATERIALS AND METHODS: Archival paraffin-embedded tissues from 37 patients with TCC were analysed by immunohistochemistry to determine Fas and FasL expression. RESULTS: Fas and FasL were detected on the cell surface and cytoplasm of respectively 34 (92%) and all cases analysed. The expression of Fas and FasL did not differ with the cytological grade of TCC. CONCLUSION: The high expression of FasL in TCC, reported for the first time in the present study, suggests that FasL may contribute to the immune escape of TCC through killing Fas-bearing lymphocytes. Co-expression of Fas with FasL also suggests that TCC may have pathways resistant to Fas-mediated autocrine cell suicide. |
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