脂联素与足背动脉内膜中膜厚度

目的探讨人血清脂联素与2型糖尿病动脉粥样硬化病变程度的关系。方法收集正常人(NC组)33例、2型糖尿病非动脉粥样硬化患者(NAS组)61例、2型糖尿病动脉粥样硬化患者(AS组)66例的临床资料,分别以彩色多普勒超声测定其足背动脉血管内膜中膜厚度(IMT),采集其静脉血测定其血清脂联素及各代谢指标。结果1)IMT在AS组显著高于NC组及NAS组(P值均<0.01)。血清脂联素在AS组显著低于NAS组及NC组(P值均<0.01),进行协方差分析后,其修正均数值AS组显著低于NAS组和NC组,差异均有统计学意义(P<0.05)。2)多元逐步回归表明,三酰甘油、体质量指数、IMT、收缩压、餐后血糖、尿酸分别为血清脂联素的独立相关因素,表现为负性相关影响。结论血管IMT作为动脉粥样硬化的良好客观指标,其与脂联素具有明显的负相关。

Adiponectin and Intima Media Thickness of Dorsalis Pedis Artery

Objective To investigate whether the serum adiponectin is related to the atherosclerosis in type 2 diabetes.Methods Thirty three normal control subjects(NC group),66 type 2 diabetes subjects without atherosclerosis(NAS group),and 66 type 2 diabetes subjects with atherosclerosis(AS group) were recruited.The intima media thickness(IMT) of dorsalis pedis artery were measured using B-mode Doppler ultrasonography.Serum adiponectin and other gluco-lipid metabolic indices were determined.Results 1)Compared with NC group and NAS group,the IMT value in AS patients were significantly increased(P<0.01 respectively),associated with lower serum adiponectin(P<0.01,respectively).After the analysis of covariance,the adjusted adiponectin value in AS group remained lower than that in NAS group and NC group(P<0.05).2)Multiple regression analysis showed that TG,BMI,SBP,PPG,UA were the main independent negative risk factors influencing serum adiponectin concentration.Conclusion As an objective index of atherosclerosis,IMT was obvious negatively associated with serum adiponectin.