| 5—羟色胺再摄取抑制对小肠传递影响的研究 |
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| 引用本文： | 张厚德 王三清. 5—羟色胺再摄取抑制对小肠传递影响的研究[J]. 胃肠病学和肝病学杂志, 1999, 8(2): 124-125 |
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| 作者姓名： | 张厚德 王三清 |
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| 作者单位： | 深圳市南山人民医院消化内科 |
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| 摘 要： | 目的探讨选择性５羟色胺再摄取抑制剂对小肠传递功能的影响。方法８名健康志愿者连续５天口服帕罗西丁，２０ｍｇ／天，于用药前一天和停药次日进行乳果糖氢呼气试验测定口－盲肠通过时间。结果口－盲肠通过时间从用药前８６±２３分钟降至用药后的６８±２０分钟，差异显著（ｔ＝３．４３９，Ｐ＜０．０５）。结论５羟色胺参与胃肠道动力调节，选择性５羟色胺再摄取抑制剂具有促小肠动力作用。
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| 关 键 词： | 5-羟色胺再摄取抑制剂 小肠传递 氢呼气试验 帕罗西丁 |
Study on effect of inhibiting 5hydroxytryptamine reuptake on small intestinal transit |
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| Zhang Houde,Wang Shanqing,Division of Gastroenterology,Internal Medicine Department,Nanshan Hospital,Shenzhen. Study on effect of inhibiting 5hydroxytryptamine reuptake on small intestinal transit[J]. Chinese Journal of Gastroenterology and Hepatology, 1999, 8(2): 124-125 |
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| Authors: | Zhang Houde Wang Shanqing Division of Gastroenterology Internal Medicine Department Nanshan Hospital Shenzhen |
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| Affiliation: | Zhang Houde,Wang Shanqing,Division of Gastroenterology,Internal Medicine Department,Nanshan Hospital,Shenzhen 518052 |
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| Abstract: | Aim To investigate effect of selective 5-hydroxytryptamine reuptake inhibitor on the small intestinal transit. Method The study consisted of 8 healthy volunteers.They received paroxetine 20 mg daily for five days.Orocaecal transit time was measured by lactulose hydrogen breath test on the day before and after administration of paroxetine. Result Orocaecal transit time was reduced by patoxetine from 8623 min to 6820 min (t=3.439,P<0.05). Conclusions 5-hydroxytryptamine participates in the control of gastrointestinal motility,and selective 5-hydroxytryptamine reuptake inhibitor has a prokinetic action in small intestine. |
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| Keywords: | 5-Hydroxytryptamine reuptake inhibitor Small intestine transit Hydrogen breath test Paroxetine |
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