Construction, expression and characterisation of a single chain anti-tumour antibody (scFv)-EL-2 fusion protein |
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| Authors: | Boleti, E. Deonarain, M. P. Spooner, R. A. Smith, A. J. Epenetos, A. A. George, A. J. T. |
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| Affiliation: | 1Protein Engineering Laboratory, Department of Immunology, Imperial Cancer Research Fund Oncology Unit, Royal Postgraduate Medical School, Hammersmith Hospital London, U.K
2Tumour Targeting Laboratory, Imperial Cancer Research Fund Oncology Unit, Royal Postgraduate Medical School, Hammersmith Hospital London, U.K |
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| Abstract: | We describe the production and preliminary characterisationof a fusion protein between interleukin-2 and a single-chainFv version of the H17E2 anti-placental alkaline phosphatase(PLAP) antibody. This molecule could be used to target interleukin-2to PLAP-expressing tumours cytokines, fusion protein, interleukin-2, monoclonal antibodies, single-chain antibodies (scFv), targeted immunotherapy |
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