| COX-2和VEGF在尖锐湿疣组织中的表达和意义 |
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| 引用本文： | 黄小雄,赵卫华,邹循辉,蔡志凌.COX-2和VEGF在尖锐湿疣组织中的表达和意义[J].岭南皮肤性病科杂志,2006,13(1):1-3,19. |
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| 作者姓名： | 黄小雄 赵卫华 邹循辉 蔡志凌 |
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| 作者单位： | 广东省惠州市皮肤病医院,广东,惠州,516008 |
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| 摘 要： | 目的:探讨尖锐湿疣(CA)组织中环氧化酶-2(COX-2)和血管内皮生长因子(VEGF)的表达及意义。方法:用SP法(免疫组织化学)分别检测COX-2和VEGF蛋白在36例CA组织和15例正常上皮组织中的表达。结果:COX-2和VEGF在正常上皮组织均有极少量弱的表达,在CA组织均呈强阳性表达;COX-2和VEGF蛋白表达呈正相关(r=0.549,P<0.01)。结论:COX-2和VEGF表达呈正相关,COX-2和VEGF在CA发生、发展中起一定作用,表明COX-2可能与肿瘤血管形成有关。
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| 关 键 词： | COX-2 VEGF 尖锐湿疣 免疫组化 |
| 文章编号： | 1009-8968（2006）01-0001-03 |
| 收稿时间： | 2005-12-08 |
| 修稿时间： | 2005年12月8日 |
Expression and Significance of COX-2 and VEGF Protein in Condyloma Acuminata |
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| HUANG Xiao-xiong,ZHAO Wei-hua,ZOU Xun-hui,CAI Zhi-ling.Expression and Significance of COX-2 and VEGF Protein in Condyloma Acuminata[J].Southern China Journal of Dermato-Venereology,2006,13(1):1-3,19. |
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| Authors: | HUANG Xiao-xiong ZHAO Wei-hua ZOU Xun-hui CAI Zhi-ling |
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| Abstract: | Objective:To detect COX-2 and VEGF protein in keratinocytes of condyloma acuminatum(CA),and explore their roles in pathogenesis. Methods:The expression of COX-2 and VEGF protein in 36 cases of CA and 15 normal controls were detected respectively by immunohistochemistry staining.Results: There were no expression of COX-2 and VEGF in normal skin tissue,while there were overexpression of COX-2 and VEGF in CA tissue;there was a statistically positive correlation between COX-2 and VEGF protein overexpression in CA(r=0.549,P<(0.01).)Conclusion:There is a statistically positive correlation between COX-2 and VEGF protein overexpression in CA;the study indicated that overexpression of COX-2 protein in CA is related with tumour blood vessel formation. |
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| Keywords: | COX-2 VEGF Aondyloma acuminatum Immunohistochemistry |
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