氟硒联合毒性作用的研究

研究了氟硒对水生物大型水蚤和挠足动物及哺乳动物小鼠的联合毒性。在本实验条件下,NaF的毒性半数致死浓度LC_(50)(48h)对大型水蚤为390mg/L,对挠足动物为295mg/L,对小鼠半数致死量LD_(50)为260mg/L;Na_2SeO_3的毒性LC_(50)(48h)对大型水蚤为1.6mg/L,对挠足动物为15.3mg/L,对小鼠的LD_(50)为33.6mg/kg,这些结果呈一定的规律,且均是亚硒酸钠的毒性远大于氟化钠。氟硒联合作用水生物实验采用毒性单位法及相加指数法进行评价,动物实验采用Q值进行评价,结果显示氟硒配比浓度(剂量组合)低时或低硒高氟时的联合作用以拮抗为主,特别是对大型水蚤氟硒比为10:1时拮抗作用最强;高硒高氟时,尤其对小鼠的联合急性毒性以协同作用为主。

Studies on combined toxicities of fluoride and selenite

The combined toxic effects of selenite and fluoride to aquatic organism (Daphnia magna and Ni tocra) and mammal (mouse) were studied. The LC_(50) (48h) of NaF toxicity to Daphnia was 390mg/L, to Nitocra was 295mg/L, and LD_(50) to mouse was 260mg/kg. LC_(50)(48h) of Na_2SeO_3to Daphnia was 1.6mg/L, to Nitocra was 15.3mg/L, LD_(50) to mouse was 33.6mg/kg. These results showed the toxicities of Na_2SeO_3 were higher than NaF. The toxicity unit method (TU) and addition index method (AI)were used in the evaluation of the combined toxicities of NaF and Na_2SeO_3 (Na_2SeO_4) to apustic organism, and Qvalue was used for mice. The results showed that the combined effects of fluoride and selenite to Daphnia and Nitocra were also antagonitic in different concentrations, to mouse were mainly synergic effect.