苯的两种生物标志物现场应用价值的比较

选择了８６名苯接触工人进行现场研究。结果表明当空气苯浓度的几何均值为３１．８６ｍｇ／ｍ３时，代谢物粘康酸的几何均值为３．１５３ｍｇ／ｇ，尿酚则为３１．０２７ｍｇ／ｇ。接触的空气苯浓度分别与代谢物粘康酸和尿酚之间的相关系数为０．９０１２、０．７３０１。接触低浓度苯的人群尿酚与外接触的苯水平相关性较差；但粘康酸无论是在接触高的或低的苯浓度情况下，二者之间均有良好的相关性。粘康酸在对照组检出水平极低。提示：粘康酸可替代尿酚作为苯的生物学监测指标

Study on urinary phenol and t,t MA as biomarkers for workers exposed to benzene

Trans, trans muconic acid ( t,t MA) was determined by revised high performance liquid chromatograph in 86 benzene exposed workers, and corresponding urinary phenol levels were compared. Air benzene was also detected as the dose of benzene exposure. The results showed that the geometric mean of benzene in the air was 31.86mg/m 3. The urinary t,t MA and phenol levels were 31.53 and 31.027mg/g respectively. The correlation coefficients were respectively 0.9012 and 0.7301 between air benzene and t,t MA and between air benzene and urinary phenol. In low benzene exposed workers, the correlation between urinary phenol and air benzene was poor. But the correlations between urinary t,t MA and air benzene in low or high benzene exposed workers was good. The background levels of t,t MA in control group was very low. The content of urinary phenol might be replaced by urinary t,t MA as a sensitive biological indicator for monitoring benzene exposure.