钙、镁和蛋白质摄入量对氟中毒及氟耐受量影响的研究

研究了一个典型的饮水型氟中毒病区人群钙、镁、蛋白质摄入量及其对氟中毒和人群氟耐受量的影响。结果表明，在暴露区中儿童的平均钙、镁、蛋白质人均日摄入量分别为３９２ｍｇ、４４２ｍｇ和４４．２ｇ；成人平均钙、镁、蛋白质日摄入量分别为４８８ｇ、５６６ｍｇ和５３．６ｇ，二者之间存在显著性差异。对上述数据进行Ｌｏｇｉｓｔｉｃ回归分析表明，钙、镁与氟斑牙呈明显的负相关关系，钙、镁、蛋白质均与氟中毒的症状和体征呈负相关关系。提示钙、镁、蛋白质对氟斑牙、成人氟中毒的症状与体征具有拮抗作用。在同一患病率下，钙、镁、蛋白质对氟中毒的拮抗作用镁＞钙＞蛋白质。增加钙、镁、蛋白质摄入量可以提高人群氟耐受量

Study on the effect of total intakes of calcium, magnesium and protein on fluorosis and fluoride tolerance

The total intakes of calcium, magnesium and protein of population in a typical area with water borne fluorosis and their effects on the tolerable intake of fluoride were investigated. The results show that the average intakes of calcium, magnesium and protein for children in the exposure areas were 392 mg/person/day, 442 mg/person/day and 44.2g/person/day, respectively, whereas those of calcium,magnesium and protein for adults were 488 mg/person/day, 566 mg/person/day and 53.6g/person/day, respectively. There was significant difference between children and adults in total intakes of calcium,magnesium and protein. It was demonstrated by using logistic regression analysis that the intakes of calcium and magnesium were negatively correlated to dental caries, and the intakes of calcium, magnesium and protein were also negatively correlated to fluorosis. Our investigations suggested that calcium, magnesium and protein have antagonic effects on dental caries and the signs of fluorosis in adults. At the same morbidity rate, the antagonic effects of calcium,magnesium and protein on fluorosis have the following trends: magnesium>calcium>protein. It is concluded that the maxium tolerable intake of fluoride of population increases with the increased intakes of calcium, magnesium and protein.