矽肺病人的肾功能损害研究

测定了99例矽肺病人和32例对照人群尿白蛋白(Alb)、β_2-微球蛋白(β_2-mG)和N-乙酰-β-D-氨基葡萄糖苷酶(NAG)排泄量。结果表明,矽肺病人尿Alb(P<0.001)、β_2-mG(P<0.01)和NAG(P<0.001)均显著高于对照组,而且尿Alb、β_2-mG和NAG增加与矽肺期别、脱离接尘时间无关,而与接尘时间长短有关。证实二氧化硅粉尘可导致接触者慢性非可逆性的肾功能损害。

Study on renal dysfunction of silicotic patients

This study observed the relation between renal alteration and the exposure to silica by measuring uriary excretion of albumin (Alb), β-2-microglobulin (β_2-mG) and N-acetyl-β-D-glucosaminidase (NAG) in 99 silicotic patients and 32 controls. The results showed that silicotic patients had significantly higher excretion of Alb (P<0.001), β_2-mG (P<0.01) and NAG (P<0.001) than the controls had. This increase did not correlate with the stages of silicosis, nor with the duration of exposure fermination. However, it correlated with the duration of exposure. Our study suggests that exposure to silica dust is associated with chronic irreversible renal dysfunction in exposed workers.