地方性氟疾病与膳食营养水平关系研究

按统一研究设计和方法，对水氟浓度和营养状况不同的６个地区和煤氟含量不同的４个地区环境氟水平及１２００多名４０～６０岁居民的膳食营养、总摄氟量、氟中毒等流行病学及生化指标进行了综合调查分析。结果显示：高氟和营养不足地区的氟中毒检出率显著高于总摄氟量相近而营养正常地区，证实人体营养状况特别是钙与蛋白质对氟化物吸收利用确有一定影响。调查发现：摄入过量氟可能使体内清除自由基的能力降低；在相同氟水平下，营养正常人群血浆过氧化物歧化酶和丙二醛均高于营养不足地区。但在各调查点，未发现暴露的氟化物对人体有遗传毒性以及血浆中一般生化指标和微量元素与氟和营养水平有明显一致的规律性

Study on the relationship between endemic fluorosis and dietary nutrition level

In 1992～1994, a comprehensive study was designed by an unified plan and methods on the dietary nutrition, total fluoride intake, fluorosis prevalence and biochemical indexes of 1200 subjects aged 40￣60 years and on environmental fluoride level in 6 areas with low, middle and high fluoride concentrations in drinking water, and in 4 areas with low and high fluoride contents in coal. Results showed that the incidence of fluorosis in the areas with high fluoride intake and low nutritional status were obviously higher than that in the areas with similar fluoride intake but normal nutrition level. The results indicated that nutritional status, protein and calcium in particular, had influence on the toxic effects of fluoride. It was also found that fluoride exposure has no genotoxic potential for subjects in the areas surveyed. The excessive fluoride intake is likely to reduce the ability of eliminating free radicals in the body. The serum SOD and MDA levels of the subjects in the areas with normal nutrition were significantly higher than that in the areas with low nutrition. The close corelation between the biochemical indices and trace elements in plasma with the fluoride and nutritional status has not been found.