| 长期低铅染毒对大鼠心肌微粒体膜脂质过氧化影响 |
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| 引用本文： | 王桂兰,刘双军,吕萍,刘智敏. 长期低铅染毒对大鼠心肌微粒体膜脂质过氧化影响[J]. 卫生研究, 1996, 25(5): 265-267 |
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| 作者姓名： | 王桂兰 刘双军 吕萍 刘智敏 |
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| 作者单位： | 河北医科大学毒理教研室 |
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| 摘 要： | 分别以醋酸铅（ＰｂＡｃ２）１０，３０和９０ｍｇ／（ｋｇ·ｄ）给雄性ＳＤ大鼠灌胃，连续９周，结果表明心肌微粒体膜（ＭＭＳ）Ｎａ＋，Ｋ＋－ＡＴＰ酶（Ｎａ泵）、超氧化物歧化酶活性、血锌含量降低，ＭＭＳ丙二醛、血和尿铅、胸主动脉Ｃａ２＋含量及ＭＭＳＣａ２＋－ＡＴＰ酶（Ｃａ泵）活性增高，与对照组比较均呈显著性差异。离体大鼠ＭＭＳ单独与不同浓度（０．３，０．６，１．２ｍｍｏｌ／Ｌ）ＰｂＡｃ２共同温育后，除Ｃａ泵活性下降外，出现与体内同样毒性作用。结果提示小剂量ＰｂＡｃ２使ＭＭＳ酶的损害和抗氧化能力降低在铅中毒性心肌损伤中具有重要的作用
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| 关 键 词： | 醋酸铅心肌 微粒体膜 Na＋，K＋－ATP酶 Ca2＋－ATP酶 |
Lipid peroxidation of myocardial microsome membrane in rats chronically poisoned with low levels of lead |
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| Wang Guilan, Liu Shuangjun, L Ping, Liu Zhimin. Lipid peroxidation of myocardial microsome membrane in rats chronically poisoned with low levels of lead[J]. Journal of hygiene research, 1996, 25(5): 265-267 |
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| Authors: | Wang Guilan Liu Shuangjun L Ping Liu Zhimin |
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| Abstract: | ur study revealed the decrease of myocardial microsomes(MMS) Na +,K + ATPase activities, super oxide dismutase (SOD) activities and contents of blood zince, the elevation of malondialdehydo (MDA), Ca 2+ ATPase activities, levels of blood lead, urinary lead and calcium (Ca 2+ ) in thoracic aorta in male SD rats by repeative gavage at the doses of 10, 30 and 90 mg/(kg·d) lead acetatic (PbAc 2) for 9 weeks. The differences were significant between the experimental and control groups. The in vitro and in vivo tests showed the same results except the decline of Ca 2+ ATPase activities in vitro. The impairment of enzymes and the decline of anti LPO function of MMS play an important role in low dose lead induced myocardium toxicity. |
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| Keywords: | lead acetatic myocardial microsome Na K ATPase Ca 2 ATPase |
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