中晚期宫颈癌三维适形放疗联合介入化疗的疗效分析

目的探讨三维适形放射治疗（three-dimensional conformal radiation therapy,3DCRT）＋介入化疗治疗中、晚期宫颈癌的疗效。方法 2008年3月-2009年3月选取80例在本院被确诊为Ⅱb~Ⅲ期的宫颈癌患者为研究对象,将其随机分为试验组（n=40,三维适形放疗＋介入化疗）和对照组（n=40,三维适形放疗＋静脉化疗）（研究遵循程序符合本院人体试验委员会制定的伦理学标准,得到该委员会批准,分组征得患者知情同意,并与患者签署临床研究知情同意书）,比较两组疗效和不良反应,并随访2年以上。结果试验组患者完全缓解率、2年生存率均高于对照组,两组比较差异有统计学意义（P〈0.05）;骨髓抑制、胃肠道系统不良反应严重程度明显低于对照组,两组比较差异有统计学意义（P〈0.05）;泌尿系统不良反应两组比较,差异无统计学意义（P〉0.05）。结论三维适形放疗＋介入化疗是治疗中、晚期宫颈癌的有效方法,不良反应程度轻、疗效高,值得临床上推广应用。

Efficacy of Three-dimensional Conformal Radiation Therapy Combined with:Interventional Chemotherapy for Intermediate and Advanced Cervical Cancer

Objective To study the therapeutic efficacy of three-dimensional conformal radiation therapy(3DCRT) combined with interventional chemotherapy for intermediate and advanced cervical cancer. Methods From March,2008 to March,2009,80 women with histologically confirmed cervical cancer at IIb～III stage were randomly divided into experimental group (n=40) which received three-dimensional conformal radiation therapy combined with interventional chemotherapy and control group(n=40) which received three-dimensional conformal radiation therapy combined with intravenous chemotherapy.Efficacy and side effects were compared between the two groups,and all patients were followed-up more than 2 years.Informed consent was obtained from all participates. Results Complete remission(CR) rate and 2-year survival rate of experimental group were significantly higher than those of control group(P<0.05).Side effects of gastrointestinal tract and myelosuppression of experimental group were less serious than those of control group,and the difference was statistically significant(P<0.05).There had no statistically significant difference in side effects of urinary system between the two groups(P>0.05). Conclusions Three-dimensional conformal radiation therapy combined with interventional chemotherapy could improve the clinical efficacy,and with less side effects.It is an effective treatment for intermediate and advanced cervical cancer and worthy to be popularized in clinical practice.