达英-35联合二甲双胍治疗38例多囊卵巢综合征

目的:观察达英-35联合二甲双胍治疗多囊卵巢综合征(PCOS)的临床疗效。方法:38例临床患者,口服达英-35和二甲双胍3个周期,观察治疗前后临床症状、性激素水平、瘦素(Lp)、胰岛素抵抗指数(HOMA-IR)、性激素结合球蛋白(SHBG)、体重指数(BMI)和卵巢形态学等指标,比较生殖内分泌指标及糖代谢指标的变化。结果:用药后LH/FSH比值、雄激素水平、瘦素和胰岛素抵抗指数较治疗前均降低,性激素结合球蛋白较治疗前显著升高(P<0.01)。治疗后BMI下降(P<0.05),卵巢体积较治疗前明显缩小(P<0.05)。结论:达英-35联合二甲双胍可有效改善多囊卵巢综合征患者的胰岛素抵抗状态,降低血中雄激素水平并恢复生育功能,治疗多囊卵巢综合征安全有效。

Effects of Diane-35 Combined with Metformin on Treatment of Polycystic Ovary Syndrome

Objective: To investigate the clinical effects of Diane-35 with metformin on treating women with polycystic ovary syndrome(PCOS). Method: Thirty-eight patients took orally Diane-35 and metformin for 3 consecutive courses of treatment.Clinical symptoms,luteinizing hormone(LH),follicle stimulating hormone(FSH),T,Leptin,HOMA-IR,SHBG,BMI and the ovarian volume were kept under observation before and after taking Diane-35 and metformin.Reproductive hormones,serum glucose and insulin level were compared to that before therapy. Result: The content of LH/FSH,androgen,HOMA-IR were less than that before the treatmennt.The content of SHBG was more than that before taking medicine,and there were highly significant difference (P<0.01).The content of BMI was less than that before taking medicine,the size of ovaries was reduced and there were significant difference (P<0.05). Conclusion: Diane-35 and metformin are effective to reduce insulin resistance and androgen and to recover ovulation in women with PCOS.And the treatment was shown to be safe and effective.