| 大鼠失神经支配后比目鱼肌和趾长伸肌超微结构变化的实验研究 |
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| 引用本文： | 李枚原,薛成斌,韦中亚,朱昌来,张沛云,顾晓松.大鼠失神经支配后比目鱼肌和趾长伸肌超微结构变化的实验研究[J].中国交通医学杂志,2011,25(2):107-109. |
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| 作者姓名： | 李枚原 薛成斌 韦中亚 朱昌来 张沛云 顾晓松 |
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| 作者单位： | 南通大学神经再生重点实验室,江苏,226001 |
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| 基金项目： | 国家"863"计划重大项目，江苏省自然科学创新攀登项目，江苏高校优势学科建设工程资助项目 |
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| 摘 要： | 目的:探讨比目鱼肌和趾长伸肌失神经支配后不同时间点超微结构变化。方法:建立SD大鼠坐骨神经离断模型,分别于术后1,2,3,4周电镜下观察大鼠比目鱼肌和趾长伸肌的超微结构变化。结果:失神经支配1周,比目鱼肌纤维局部萎缩变细,肌丝排列不规则,部分线粒体出现肿胀;趾长伸肌的肌丝排列稍不规则,线粒体形态等无明显异常。失神经支配2周比目鱼肌萎缩变细加重,肌节与肌丝排列紊乱,部分线粒体空泡变性;趾长伸肌的肌丝局部萎缩变细,肌间隙增宽,线粒体发生轻微肿胀。失神经支配后3、4周,比目鱼肌肌节肌丝变化明显,结构模糊不清,线粒体呈空泡化;趾长伸肌的肌丝排列不规则,肌原纤维结构可辨,线粒体肿胀明显,部分出现空泡化。结论:周围神经损伤可致骨骼肌超微结构发生明显变化,并随着失神经支配时间延长而逐渐加重;比目鱼肌失神经支配后超微结构的变化较趾长伸肌明显。
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| 关 键 词： | 失神经 比目鱼肌 趾长伸肌 萎缩 坐骨神经 大鼠 |
Ultrastructural changes after denervation of soleus and extensor digitorum longus |
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| Li Meiyuan,Xue Chengbin,Wei Zhongya,Zhu Changlai,Zhang Peiyun,Gu Xiaosong.Ultrastructural changes after denervation of soleus and extensor digitorum longus[J].Chinese Medical JOurnal of Communications,2011,25(2):107-109. |
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| Authors: | Li Meiyuan Xue Chengbin Wei Zhongya Zhu Changlai Zhang Peiyun Gu Xiaosong |
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| Institution: | Li Meiyuan,Xue Chengbin,Wei Zhongya,Zhu Changlai,Zhang Peiyun,Gu Xiaosong(Key Laboratory of Neuroregeneration,Nantong University,Jiangsu226001) |
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| Abstract: | Objective: To observe the ultrastructural changes in soleus and extensor digitorum longus at different time points after denervation.Methods: The model of denervation was established in SD rats.Soleus and extensor digitorum longus were harvested at different time points after denervation.The ultrastructures of the samples were observed by electron microscope.Results: One week after denervation,for soleus muscle,fibers became atrophied and thinner,myofilaments arranged irregularly,and some mitochondria swoll... |
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| Keywords: | denervation soleus extensor digitorum longus atrophy sciatic nerve rat |
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