| 帕罗西汀联合心理治疗脑卒中后抑郁的临床疗效 |
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| 引用本文： | 黄雯雯,林朝仙.帕罗西汀联合心理治疗脑卒中后抑郁的临床疗效[J].实用预防医学,2011,18(5):880-882. |
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| 作者姓名： | 黄雯雯 林朝仙 |
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| 作者单位： | 汕头大学医学院第一附属医院药剂科,广东,汕头,515041 |
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| 基金项目： | 广东省科技计划项目重点课题 |
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| 摘 要： | 目的探讨帕罗西汀联合心理治疗脑卒中后抑郁的治疗效果。方法将106例脑卒中后抑郁患者随机分为治疗组和对照组,对照组给予心理治疗,治疗组给予心理治疗和帕罗西汀治疗。8周后,对两组患者进行HAMD、MESSS、TESS评分,入院后采用汉密尔顿抑郁量表（HAMD）评定抑郁症状;采用放射免疫法测定两组患者血浆Cor含量。结果经过治疗,治疗组的脑卒中后抑郁的显效率为71.7%,神经功能恢复总有效率为90.6%,均显著高于对照组的43.4%和66%（P〈0.05）;治疗后两组的HAMD和MESSS评分均显著下降（P〈0.05）,两组间比较差异有统计学意义（P〈0.05）;TESS评分差异无统计学意义（P〉0.05）。帕罗西汀治疗组血浆Cor含量降低幅度较对照组更明显（P〈0.05）。结论脑卒中后抑郁患者经帕罗西汀联合心理治疗后,抑郁程度明显减轻,生活质量均明显改善,血浆Cor含量降低可能是帕罗西汀治疗脑卒中后抑郁症的一种作用机制。
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| 关 键 词： | 脑卒中后抑郁 帕罗西汀 心理治疗 |
Clinical Effect of Paroxetine Combined with Psychotherapy on Pat-stroke Depression |
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| HUANG Wen-wen,LIN Chaoxian.Clinical Effect of Paroxetine Combined with Psychotherapy on Pat-stroke Depression[J].Practical Preventive Medicine,2011,18(5):880-882. |
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| Authors: | HUANG Wen-wen LIN Chaoxian |
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| Institution: | HUANG Wen-wen,LIN Chao-xian(Department of Pharmacy,the First Affiliated Hospital of Medical College of Shantou University,Shantou 515041,Guangdong,China) |
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| Abstract: | Objective To explore the clinical efficacy of paroxetine combined with psychotherapy on post-stroke depression(PSD). Methods Totally 106 patients suffered from post-stroke depression were randomly divided into two groups: control group(psychotherapy alone) and therapeutic group(paroxetine combined with psychotherapy).Hamilton depression rating scales,MESSS and TESS were used to evaluate all the patients after admission.The serum cortisol level was detected by radioimmunity method. Results After 8 weeks of t... |
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| Keywords: | Post-stroke depression Paroxetine Psychotherapy |
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