定心胶囊对房颤大鼠血清D-二聚体的影响

目的:通过探讨定心胶囊对房颤大鼠血清D-二聚体含量的影响,揭示益气养阴活血中药预防和治疗房颤的作用机制。方法:选用体重在200～250 g的健康雄性Wistar大鼠,建立慢性房颤的动物模型。将造模成功的30只大鼠随机分为3组:模型组、定心胶囊治疗组(16.2 g·kg-1.d-1)和维拉帕米对照组(4.5 mg·kg-1.d-1),另设一组正常对照组。用药4周后,观察各组房颤大鼠血清D-二聚体的变化。结果:大鼠房颤模型组与正常对照组比较,血清D-二聚体的含量明显增加(P<0.05)。定心胶囊治疗组和维拉帕米对照组与模型组比较,可以明显地降低血清中D-二聚体的含量(P<0.05)。定心胶囊治疗组与维拉帕米对照组对房颤大鼠血清中D-二聚体的改善程度相比前者优于后者(P<0.05),有统计学意义。结论:定心胶囊能够明显降低房颤大鼠血清D-二聚体的水平,是防治房颤的有效药物。

Experimental Study on Effective Therapy of D-D for Dingxin Capsule to Rats of Atrial Fibrillation

Objective: The aim of this study is to develop the effective therapy on Dingxin capsule for D-dimer(D-D)of atrial fibrillation. To reveal the mechanism of Chinese medicine with the effects of nourishing Qi and Yin and activating blood in the prevention and treatment of Atrial Fibrillation(AF). Method :Forty rats were randomized to 4 groups:normal group,model group,Dingxin capsule curatio group,verpamil intervention group. The level of D-D of AF rats were measured. Result: With the comparison of treating group and model group,the level of D-D in treating group lowed obviously(P<0.05). Both of them had statistic significance.Both Dingxin capsule group and Verpamil intervention group could low the level of D-D,but Dingxin capsule group is better. Conclusion: Dingxin capsule could correct the level of D-D in AF rats. D-D played important role in the pathogenesis of AF.