| 一氧化氮合酶在舌鳞癌组织中的表达及其与预后的关系 |
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| 引用本文： | 陈伟良,李海刚,潘朝斌. 一氧化氮合酶在舌鳞癌组织中的表达及其与预后的关系[J]. 中华口腔医学杂志, 1998, 33(3): 152-154 |
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| 作者姓名： | 陈伟良 李海刚 潘朝斌 |
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| 作者单位： | 中山医科大学孙逸仙纪念医院口腔颌面外科 |
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| 摘 要： | 目的探讨舌鳞癌组织中一氧化氮合酶（ｎｉｔｒｉｃｏｘｉｄｅｓｙｎｔｈａｓｅ，ＮＯＳ）的表达及其与预后的关系。方法用免疫组织化学法测定ＮＯＳＩ、ＮＯＳＩ和ＮＯＳＩＩ在５５例舌鳞癌组织中的表达。结果ＮＯＳＩ、ＮＯＳＩ和ＮＯＳＩＩ阳性表达率分别为３０９％、４００％和３８２％。在有颈淋巴转移组与无淋巴转移组之间、５年生存组与５年内死亡组之间差异均有非常显著性（Ｐ＜００１）。ＮＯＳＩ在Ｇ１、Ｇ２和Ｇ３之间，临床分期之间差异有显著性（Ｐ＜００５）。结论舌鳞癌组织中ＮＯＳＩ、ＮＯＳＩ和ＮＯＳＩＩＩ的表达与其预后有关，ＮＯＳＩ对肿瘤的生长、分化、淋巴转移和预后均有重要作用
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| 关 键 词： | 癌.鳞状细胞 舌肿瘤 一氧化氮合酶 预后 |
Expression of nitric oxide synthase in squamous cell carcinoma of tongue and its prognosis |
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| Chen Weiliang,Li Haigang,Pan Chaobin,et al.. Expression of nitric oxide synthase in squamous cell carcinoma of tongue and its prognosis[J]. Chinese journal of stomatology, 1998, 33(3): 152-154 |
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| Authors: | Chen Weiliang Li Haigang Pan Chaobin et al. |
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| Affiliation: | Department of Oral and Maxillofacial Surgery, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University of Medical Sciences, Guangzhou 510120. |
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| Abstract: | Objective To study the expression of nitric oxide synthase (NOS) in squamous cell carcinoma of tongue and its prognosis.Methods The NOSI, NOSII and NOSIII of 55 cases of squamous cell carcinoma of tongue were detected by immunohistochemistry.Results The expressive rates of NOSI, NOSII and NOSIII were 30.9%, 40.0% and 38.2% respeetively. There were singnificant differences between the patients with and without neck nodal metastasis, and between the patients survival more than 5 years and less than 5 years ( P <0.01), There were differences between G 1, G 2 and G 3 and the clinical stages in NOSII ( P <0 05). Conclusion The expression of the NOSI, NOSII and NOSIII in squamous cell carcinoma of tongue is raleted to its prognosis and the NOSII plays a more important role in growth, differentiation, metastatic capability and prognosis of the tumor. |
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| Keywords: | Carcinoma squamous cell Tongue neoplasms Nitric oxide synthase Prognosis |
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