Transient neonatal distal renal tubular acidosis with secondary hyperparathyroidism |
| |
Authors: | Takashi Igarashi Yuriko Sekine Hidehiko Kawato Shigehiko Kamoshita Yoshindo Saigusa |
| |
Affiliation: | (1) Department of Paediatrics, Mejirodai Campus of Tokyo University, 3-28-6 Mejirodai, Bunkyo-ku, 112 Tokyo, Japan;(2) Department of Paediatrics, Faculty of Medicine, The University of Tokyo, Tokyo, Japan;(3) Saigusa Maternity Hospital, Tokyo, Japan |
| |
Abstract: | We describe a neonate with distal renal tubular acidosis with secondary hyperparathyroidism manifesting as hyperchloraemia, hypercalcaemia, elevated serum parathyroid hormone (PTH) and life-threatening metabolic acidosis. He exhibited general weakness, tachypnoea, dry skin and weight loss. Urinary excretion of titratable acid and ammonium was decreased. Daily alkali (2.5 mEq/kg body weight) was required to maintain a normal plasma bicarbonate (HCO3–). With alkali therapy, the fractional excretion of HCO3– was below 5%. Serum calcium and PTH were restored to normal promptly on initiation of alkali therapy. After 5 months of alkali therapy, normal growth and urine acidifying ability were restored and alkali therapy was discontinued. The acidification defect in this patient was transient. We consider this patient to be consistent with Lightwood's syndrome of transient infantile renal tubular acidosis. |
| |
Keywords: | Transient distal renal tubular acidosis Lightwood's syndrome Transient hypercalcaemia Secondary hyperparathyroidism |
本文献已被 SpringerLink 等数据库收录! |
|