Timing and quantification of bone loss in cardiac transplant recipients |
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Authors: | Johan Van Cleemput Wim Deanen Jos Nijs Piet Geusens Jan Dequeker Johan Vanhaecke |
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Institution: | (1) Department of Cardiology, University Hospital Gasthuisberg, Herestraat 49, B-3000 Leuven, Belgium;(2) Department of Cardiac Surgery, University Hospital Gasthuisberg, Herestraat 49, B-3000 Leuven, Belgium;(3) Arthritis and Metabolic Bone Disease Research Unit, University Hospital Gasthuisberg, Herestraat 49, B-3000 Leuven, Belgium |
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Abstract: | To evaluate osteopenic bone disease in heart transplant patients, we prospectively measured bone mineral density (BMD) in 33 consecutive male recipients before hospital discharge and 1 year later, using dual photon absorptiometry. At hospital discharge BMD measurement at the lumbar spine was only 90% of that expected in healthy age- and sex-matched controls (P=0.005). One year later BMD had further decreased by 8.5% at the lumbar spine and by 10.4% at the femoral neck (P=0.0001). Five patients suffered vertebral compression fractures during the 1st post-operative year. Our results indicate that osteopenia of the lumbar spine is already present at the time of hospital discharge after transplantation and that further bone loss occurs at a considerable rate during the 1st postoperative year at the lumbar spine and at the femoral neck. |
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Keywords: | Heart transplantation osteoporosis Osteoporosis heart transplantation |
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