健脾降脂散对肥胖高脂症大鼠预干扰作用

目的探讨健脾降脂散对肥胖高脂症大鼠体重、lee`s指数、体脂含量、肝体比值的影响。方法将健康雄性SD大鼠分为对照组和模型组。造模后将肥胖型大鼠随机分为治疗组、预防组、减肥茶组、高脂饲料组、基础饲料组,加正常对照组共6组。各组根据不同方法喂养4周后,测体重、体长,计算Lee`s指数;取颈总动脉血备用;取肾周及睾周脂肪垫、肝脏分别称重,计算体脂含量和肝体比值。结果治疗组体重、lee`s指数明显降低,接近正常组(P>0.05),治疗组与正常组体重及Lee`s指数明显低于其余4组,均具有统计学意义(P<0.01或P<0.05);预防组与减肥茶组无明显差异(P>0.05)。脂肪重量和体脂含量:治疗组低于其余5组,均具有统计学意义(P<0.01或P<0.05)。预防组低于减肥茶组、高脂饲料组及普通饲料组(P<0.01),与正常组相比无显著性差异(P>0.05)。肝脏湿重和肝体比值:治疗组和预防组接近于正常组,无明显差异(P>0.05);治疗组和正常组的肝脏湿重低于其余4组,肝体比值低于普通饲料与高脂饲料组,均具有统计学意义(P<0.01)。结论健脾降脂散具有降低脂肪和减轻体重的作用,效果明显优于芦荟减肥茶。

THE RESEARCH ON THE INTERFERENCE FUNCTION OF JIAN-PI-JIANG-ZHI-SAN ON THE RATS SUFFERED FROM OBESITY WITH HYPERLIPEMIA

Objective To discuss the influence of Jian-pi-jiang-zhi-san on weight, lee's index, the content of body fat, the ratio of liver and body weight. Methods Healthy male SD rats were divided into two groups, namely, the normal group and model group. After making the model, randomly sampled rats from each group to test relative index and to make sure that obesity with hyperlipemia were successfully made. 40 rats with obesity hyperlipemia were randomly divided into 5 groups and one group of normal control. They were feed by different ways, after 4 weeks, weight and length were tested, lee's index was calculated, the fat around kidneys, testides and liver were weighted separately, and the content of body fat and ratio of liver and body weight were calculated. Results Weight, lee's index reduced obviously in treated group and was close to normal group (P>0.05). Weight, lee's index in the 2 groups were significantly lower than that in other 4 groups (P<0.01 or P<0.05), there was no difference in preventive group and reducing tea group (P>0.05). The weight of fat and the content of body fat in treated group were significantly lower than that in other 5 groups (P<0.01 or P<0.05), and they were significantly lower in preventive group than that in reducing tea group, high fat food group and basic food group (P<0.01); there was no difference in preventive group and normal group (P>0.05). The wet weight of liver and the ratio of liver and body weight in treated group and preventive group were close to normal group (P>0.05). The wet weight of liver in treated group and normal group was significantly lower than that in other 4 groups (P<0.01). The ratio of liver and body weight in treated group and normal group was lower than that in basic food group and high fat food group (P<0.01). Conclusion Jian-pi-jiang-zhi-san had effect on reducing the fat and weight, was obviously better than that of the tea.