饮食限制对大鼠学习和记忆能力的影响

目的〓〖HTK〗研究饮食限制对大鼠学习、记忆能力影响的性别差异。〖HTW〗方法〓〖HTK〗SD雌、雄大鼠各40只，按性别随机分为100%进食组（对照组）、80%进食组（限制20%组）、60%进食组（限制40%组）、50%进食组（限制50%组）4组，喂养30d。测量体重，通过Morris水迷宫检测雌、雄大鼠各组的学习、记忆能力。〖HTW〗结果〓〖HTK〗限制40%组、限制50%组大鼠体质量明显下降(P＜0.05 )，雄性大鼠限制40%组和限制50%组的学习能力明显增强(P＜0.05 )，但记忆保持能力无明显改变，而雌性各组大鼠的学习和记忆能力均无明显改变。〖HTW〗结论〓〖HTK〗饮食限制对学习记忆能力的影响与性别有关。

Effects of dietary restriction on learning and memory ability in rats

Objective To explore sex-related effects of dietary restriction(DR) on learning and memory in rats.Methods Male and female rats were fed a standard rodent diet and libitum(control),80% of control(20% DR),60% of control(40% DR),or 50% of control(50% DR) for 30 days.Then,the ability of learning and memory of the male and female rats was measured by the Morris water maze.Results Body weight of the DR rats was reduced relative to the controls except that of the 20% DR group.Learning and memory retention test in the Morris maze demonstrated that 40% DR and 50% DR increased learning but not retention in male rats,whereas neither learning nor retention was affected in females.Conclusion DR produces sex-dependent effects on learning.