Age-related changes in sensitivity of rat urinary bladder to autonomic agents |
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Authors: | M G Kolta L J Wallace M C Gerald |
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Institution: | Division of Pharmacology, College of Pharmacy, The Ohio State University, Columbus, OH 43210 U.S.A. |
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Abstract: | Experiments were done to determine if age-related changes occur in autonomic regulation of rat urinary bladder. The maximum contractile responses to acetylcholine were 63% and 15% greater in isolated bladders from 29-month and 17-month animals, respectively, as compared to 7-month animals. The amounts of 3H]quinuclidinyl benzilate bound to membrane preparations were 46% and 7% greater. In contrast, no age-related changes were observed in phenylephrine-induced contraction or in isoproterenol-induced relaxation of bladder. Thus, the urinary bladder of aged rats appears to develop increased sensitivity to cholinergic stimuli because of an increase in the number of muscarinic cholinergic receptors. |
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Keywords: | Urinary bladder Autonomic agents Muscarinic receptors |
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