急性百草枯中毒167例临床分析

目的总结分析急性百草枯（PQ）中毒患者的临床特点及治疗效果，探讨急救急性百草枯（PQ）中毒的方法。方法选取蚌医附院2007年4月-2009年11月收治的167例（均为非生产性自服）百草枯中毒患者，男性67例，女性100例，年龄10—80岁，平均31．89岁。对该167例百草枯中毒患者临床资料进行回顾性分析。结果167例中毒者存活52例，死亡115例，病死率为68．9％。其中口服量〈20ml 39例，死亡19例；口服量20—50ml51例，死亡34例；口服量50～100ml 43例，死亡30例；口服量〉100ml34例，死亡32例。在服毒3h内和3h后经洗胃的患者，病死率分别为64．3％和78．2％；服毒12h内血液灌流治疗58例，死亡39例，病死率67．2％。结论百草枯中毒预后与中毒剂量的大小、初始洗胃时间关系密切；早期血液净化治疗可作为综合治疗的手段之一。

Clinical Analysis of 167 Patients with Acute Paraquat Poisoning

Objective To summarize the clinical characteristics of acute paraquat（PQ） poisoning and the emergency treatment. Methods The clinical data of 167 patients with acute paraquat（PQ） poisoning（commit suicide by taking poison） from Apr. 2007 to Nov. 2009 were retrospectively analyzed. There were 67 male cases and 100 female cases,and the age was from 10 to 80 years old（ mean 31.89）. Results Fifty-two in 167 cases were survival and the mortality rate was 68.9%. 19 cases died in the 39 cases whose total intake of PQ was less than 20 ml;34 cases died in the 51 cases whose total intake was 20 to 50 ml;30 cases died in the 43 cases whose total intake was 50 to 100 ml;32 cases died in the 34 cases whose total intake was more than 100 ml. The mortality rate was 64.3% in patients who received gastric lavage within 3 hours after the poisoning and 78.2% in patients who received gastric lavage exceeding 3 hours after the poisoning, respectively. 39 cases died in 58 cases who received hemoperfu- sion within 12 hours after the poisoning and the mortality rate was 67.2%. Conclusion The prognosis of patients with PQ poi- soning was close related to the total intake and the beginning of initial gastric lavage. The early hemoperfusion is one of the effective comprehensive treatment methods.