94例耐多药结核病患者抑郁状态与社会支持的调查分析

目的 调查耐多药结核病（multidrug-resistant tuberculosis，MDR-TB）患者的抑郁状态与社会支持情况，并探讨二者之间的相关因素。 方法 采用1∶1配比对照研究，对94例MDR-TB患者及相同数量的对照（从MDR-TB户籍同区的人群中选取）使用Zung抑郁自评量表（SDS）、社会支持评定量表（SSRS）进行问卷调查。调查MDR-TB患者96例，发出问卷96份，回收有效问卷94份，有效率97.9%，将有效回答的94例患者全部纳入MDR-TB组。调查MDR-TB患者户籍同区的人群，发出问卷718份，回收有效问卷676份，有效率94.2%；从676例户籍同区的人群中按照与MDR-TB患者同性别、年龄相近（相差≤2岁）原则进行1∶1配对，选取94例纳入对照组。将两组调查的SDS与SSRS问卷进行统计，对所获得的数据资料进行处理，采用双变量相关分析、t检验及单因素方差分析，P<0.05为差异有统计学意义。 结果 94例MDR-TB患者SDS得分为（52.80±8.34）分，高于对照组得分（41.81±10.26）分（t=8.284, P<0.01），45例MDR-TB患者存在抑郁状态；MDR-TB患者获得的社会支持总分为（35.65±5.47）分，少于对照组得分（41.80±6.62）分，差异有统计学意义（t=6.457，P<0.01）；MDR-TB患者SDS得分与社会支持总分呈负相关（r=－0.520，P<0.01），即获得的社会支持得分越高，抑郁症状越轻。 结论 多数MDR-TB患者存在抑郁状态，应该重视社会支持系统，改善MDR-TB患者的抑郁状态，以提高其生活质量。

Depression and social support status of multidrug-resistant tuberculosis patients

Objective To investigate the depression and social support status of multidrug-resistant tuberculosis（MDR-TB） patients,and to explore the correlation between the two factors.Methods Ninety-four MDR-TB patients in case group and 94 people selected from the same area of MDR-TB patients＇ household register in control group were investigated by Zung Self-Rating Depression Scale（SDS） and Social Support Rating Scale（SSRS）.Ninety-six questionnaires were issued for MDR-TB patients and 94 valid were returned with the effective response rate of 97.9%.All these 94 patients were enrolled in case group.718 questionnaires were issued for people selected from the same area of MDR-TB cases＇ household register and 676 valid were returned with the effective response rate of 94.2%.Among these 676 people,94 people were selected with the same gender and age（≤ 2 years＇ difference） of cases（1∶1 matched pair）.Bivariate correlation analysis,t-test and one-way analysis of variance were applied.Results The average SDS score of case group was（52.80±8.34）,which was higher than the control group（41.81±10.26）（t=8.284,P0.01）,45 patients were depressed;MDR-TB patients（35.65±5.47） received less support from the society than the control group（41.80±6.62）（t=6.457,P0.01）,the difference was statistically significant.The SDS score of MDR-TB patients was negatively correlated with the total score of social support（r=-0.520,P0.01）,which indicated the more social support the patients got,the less depressive symptoms they had.Conclusion Attention should be paid to the social support system and improvement of MDR-TB patients＇ depression in order to improve the quality of their lives.